What (H)IF isoform matters? : A deubiquitinase can tune the hypoxic response
(2022) In EMBO Journal 41(7).- Abstract
Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood. In this issue, Zhang et al (2022) identify a deubiquitinase that differentially stabilizes HIF-2alpha in stem-like glioblastoma cells, suggesting potential implications for regulation of the hypoxic response in a wide array of tissues and cancers.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/823e2b9c-85f5-402d-8f53-67a82b84474d
- author
- Pietras, Alexander LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- EMBO Journal
- volume
- 41
- issue
- 7
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85125889846
- pmid:35199359
- ISSN
- 1460-2075
- DOI
- 10.15252/embj.2022110819
- language
- English
- LU publication?
- yes
- additional info
- © 2022 The Author.
- id
- 823e2b9c-85f5-402d-8f53-67a82b84474d
- date added to LUP
- 2022-03-14 10:45:59
- date last changed
- 2024-09-19 20:44:35
@misc{823e2b9c-85f5-402d-8f53-67a82b84474d, abstract = {{<p>Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood. In this issue, Zhang et al (2022) identify a deubiquitinase that differentially stabilizes HIF-2alpha in stem-like glioblastoma cells, suggesting potential implications for regulation of the hypoxic response in a wide array of tissues and cancers.</p>}}, author = {{Pietras, Alexander}}, issn = {{1460-2075}}, language = {{eng}}, number = {{7}}, publisher = {{Oxford University Press}}, series = {{EMBO Journal}}, title = {{What (H)IF isoform matters? : A deubiquitinase can tune the hypoxic response}}, url = {{http://dx.doi.org/10.15252/embj.2022110819}}, doi = {{10.15252/embj.2022110819}}, volume = {{41}}, year = {{2022}}, }