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What (H)IF isoform matters? : A deubiquitinase can tune the hypoxic response

Pietras, Alexander LU (2022) In EMBO Journal 41(7).
Abstract

Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood. In this issue, Zhang et al (2022) identify a deubiquitinase that differentially stabilizes HIF-2alpha in stem-like glioblastoma cells, suggesting potential implications for regulation of the hypoxic response in a wide array of tissues and cancers.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
EMBO Journal
volume
41
issue
7
publisher
Oxford University Press
external identifiers
  • scopus:85125889846
  • pmid:35199359
ISSN
1460-2075
DOI
10.15252/embj.2022110819
language
English
LU publication?
yes
additional info
© 2022 The Author.
id
823e2b9c-85f5-402d-8f53-67a82b84474d
date added to LUP
2022-03-14 10:45:59
date last changed
2025-11-15 12:05:19
@misc{823e2b9c-85f5-402d-8f53-67a82b84474d,
  abstract     = {{<p>Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood. In this issue, Zhang et al (2022) identify a deubiquitinase that differentially stabilizes HIF-2alpha in stem-like glioblastoma cells, suggesting potential implications for regulation of the hypoxic response in a wide array of tissues and cancers.</p>}},
  author       = {{Pietras, Alexander}},
  issn         = {{1460-2075}},
  language     = {{eng}},
  number       = {{7}},
  publisher    = {{Oxford University Press}},
  series       = {{EMBO Journal}},
  title        = {{What (H)IF isoform matters? : A deubiquitinase can tune the hypoxic response}},
  url          = {{http://dx.doi.org/10.15252/embj.2022110819}},
  doi          = {{10.15252/embj.2022110819}},
  volume       = {{41}},
  year         = {{2022}},
}