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Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium

Truong, Thérèse ; Lesueur, Fabienne ; Thomsen, Hauke LU orcid ; Forsti, Asta LU ; Guénel, Pascal and de Vathaire, Florent (2021) In International Journal of Cancer 148(12). p.2935-2946
Abstract

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the... (More)

Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the EPITHYR consortium. All participants were genotyped using the OncoArray-500K Beadchip (Illumina). We confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 and 16q23.2, which were associated with thyroid-stimulating hormone levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. We also observed that the frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans. However, additional GWAS and epidemiological studies in Oceanian populations are needed to fully understand the highest incidence observed in these populations.

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author
; ; ; ; and
author collaboration
publishing date
type
Contribution to journal
publication status
published
subject
keywords
case-control study, genome-wide association study, thyroid cancer
in
International Journal of Cancer
volume
148
issue
12
pages
2935 - 2946
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85101759864
  • pmid:33527407
ISSN
0020-7136
DOI
10.1002/ijc.33488
language
English
LU publication?
no
additional info
Publisher Copyright: © 2021 UICC Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
id
8242eb66-5857-42c6-abed-e855426eadde
date added to LUP
2021-03-15 07:51:00
date last changed
2024-04-04 01:29:01
@article{8242eb66-5857-42c6-abed-e855426eadde,
  abstract     = {{<p>Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the EPITHYR consortium. All participants were genotyped using the OncoArray-500K Beadchip (Illumina). We confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 and 16q23.2, which were associated with thyroid-stimulating hormone levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. We also observed that the frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans. However, additional GWAS and epidemiological studies in Oceanian populations are needed to fully understand the highest incidence observed in these populations.</p>}},
  author       = {{Truong, Thérèse and Lesueur, Fabienne and Thomsen, Hauke and Forsti, Asta and Guénel, Pascal and de Vathaire, Florent}},
  issn         = {{0020-7136}},
  keywords     = {{case-control study; genome-wide association study; thyroid cancer}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2935--2946}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium}},
  url          = {{http://dx.doi.org/10.1002/ijc.33488}},
  doi          = {{10.1002/ijc.33488}},
  volume       = {{148}},
  year         = {{2021}},
}