Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium
Truong, Thérèse ; Lesueur, Fabienne ; Thomsen, Hauke LU
; Forsti, Asta
LU
; Guénel, Pascal
and de Vathaire, Florent
(2021)
In International Journal of Cancer
148(12).
p.2935-2946
- Abstract
Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the... (More)
Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the EPITHYR consortium. All participants were genotyped using the OncoArray-500K Beadchip (Illumina). We confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 and 16q23.2, which were associated with thyroid-stimulating hormone levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. We also observed that the frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans. However, additional GWAS and epidemiological studies in Oceanian populations are needed to fully understand the highest incidence observed in these populations.
(Less)
- author
- Truong, Thérèse
; Lesueur, Fabienne
; Thomsen, Hauke
LU
; Forsti, Asta
LU
; Guénel, Pascal
and de Vathaire, Florent
- author collaboration
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- case-control study, genome-wide association study, thyroid cancer
- in
- International Journal of Cancer
- volume
- 148
- issue
- 12
- pages
- 2935 - 2946
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:33527407
- scopus:85101759864
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.33488
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 UICC Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
- id
- 8242eb66-5857-42c6-abed-e855426eadde
- date added to LUP
- 2021-03-15 07:51:00
- date last changed
- 2024-06-13 08:44:06
@article{8242eb66-5857-42c6-abed-e855426eadde,
abstract = {{<p>Incidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1554 cases/1973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population-based case-control studies participating to the EPITHYR consortium. All participants were genotyped using the OncoArray-500K Beadchip (Illumina). We confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 and 16q23.2, which were associated with thyroid-stimulating hormone levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. We also observed that the frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans. However, additional GWAS and epidemiological studies in Oceanian populations are needed to fully understand the highest incidence observed in these populations.</p>}},
author = {{Truong, Thérèse and Lesueur, Fabienne and Thomsen, Hauke and Forsti, Asta and Guénel, Pascal and de Vathaire, Florent}},
issn = {{0020-7136}},
keywords = {{case-control study; genome-wide association study; thyroid cancer}},
language = {{eng}},
number = {{12}},
pages = {{2935--2946}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium}},
url = {{http://dx.doi.org/10.1002/ijc.33488}},
doi = {{10.1002/ijc.33488}},
volume = {{148}},
year = {{2021}},
}