Ceruloplasmin functional changes in Parkinson's disease-cerebrospinal fluid.
(2015) In Molecular Neurodegeneration 10(1).- Abstract
- Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by deamidation of specific NGR-motifs that foster the gain of integrin-binding function. Here we investigated whether the loss of ceruloplasmin ferroxidase activity in the CSF of PD patients was accompanied by NGR-motifs deamidation and gain of function.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8243086
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Neurodegeneration
- volume
- 10
- issue
- 1
- article number
- 59
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26537957
- scopus:84946106830
- pmid:26537957
- ISSN
- 1750-1326
- DOI
- 10.1186/s13024-015-0055-2
- language
- English
- LU publication?
- yes
- id
- e841729c-e29b-457b-83da-cacf8884f1ae (old id 8243086)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26537957?dopt=Abstract
- date added to LUP
- 2016-04-01 13:30:57
- date last changed
- 2022-03-21 19:02:48
@article{e841729c-e29b-457b-83da-cacf8884f1ae, abstract = {{Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by deamidation of specific NGR-motifs that foster the gain of integrin-binding function. Here we investigated whether the loss of ceruloplasmin ferroxidase activity in the CSF of PD patients was accompanied by NGR-motifs deamidation and gain of function.}}, author = {{Barbariga, Marco and Curnis, Flavio and Andolfo, Annapaola and Zanardi, Alan and Lazzaro, Massimo and Conti, Antonio and Magnani, Giuseppe and Volontè, Maria Antonietta and Ferrari, Laura and Comi, Giancarlo and Corti, Angelo and Alessio, Massimo}}, issn = {{1750-1326}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Molecular Neurodegeneration}}, title = {{Ceruloplasmin functional changes in Parkinson's disease-cerebrospinal fluid.}}, url = {{https://lup.lub.lu.se/search/files/3417538/8863382}}, doi = {{10.1186/s13024-015-0055-2}}, volume = {{10}}, year = {{2015}}, }