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Ceruloplasmin functional changes in Parkinson's disease-cerebrospinal fluid.

Barbariga, Marco LU ; Curnis, Flavio; Andolfo, Annapaola; Zanardi, Alan; Lazzaro, Massimo; Conti, Antonio; Magnani, Giuseppe; Volontè, Maria Antonietta; Ferrari, Laura and Comi, Giancarlo, et al. (2015) In Molecular Neurodegeneration 10(1).
Abstract
Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by deamidation of specific NGR-motifs that foster the gain of integrin-binding function. Here we investigated whether the loss of ceruloplasmin ferroxidase activity in the CSF of PD patients was accompanied by NGR-motifs deamidation and gain of function.
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publication status
published
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Molecular Neurodegeneration
volume
10
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26537957
  • scopus:84946106830
ISSN
1750-1326
DOI
10.1186/s13024-015-0055-2
language
English
LU publication?
yes
id
e841729c-e29b-457b-83da-cacf8884f1ae (old id 8243086)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26537957?dopt=Abstract
date added to LUP
2015-12-02 23:12:45
date last changed
2017-07-30 04:03:37
@article{e841729c-e29b-457b-83da-cacf8884f1ae,
  abstract     = {Ceruloplasmin, a ferroxidase present in cerebrospinal fluid (CSF), plays a role in iron homeostasis protecting tissues from oxidative damage. Its reduced enzymatic activity was reported in Parkinson's disease (PD) contributing to the pathological iron accumulation. We previously showed that ceruloplasmin is modified by oxidation in vivo, and, in addition, in vitro by deamidation of specific NGR-motifs that foster the gain of integrin-binding function. Here we investigated whether the loss of ceruloplasmin ferroxidase activity in the CSF of PD patients was accompanied by NGR-motifs deamidation and gain of function.},
  articleno    = {59},
  author       = {Barbariga, Marco and Curnis, Flavio and Andolfo, Annapaola and Zanardi, Alan and Lazzaro, Massimo and Conti, Antonio and Magnani, Giuseppe and Volontè, Maria Antonietta and Ferrari, Laura and Comi, Giancarlo and Corti, Angelo and Alessio, Massimo},
  issn         = {1750-1326},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Molecular Neurodegeneration},
  title        = {Ceruloplasmin functional changes in Parkinson's disease-cerebrospinal fluid.},
  url          = {http://dx.doi.org/10.1186/s13024-015-0055-2},
  volume       = {10},
  year         = {2015},
}