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Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.

Westerlind, Helga; Mellander, Marie-Rose; Bresso, Francesca; Munch, Andreas; Bonfiglio, Ferdinando; Assadi, Ghazaleh; Rafter, Joseph; Hübenthal, Matthias; Lieb, Wolfgang and Källberg, Henrik, et al. (2017) In Gut 66. p.421-428
Abstract
Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role.
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Gut
volume
66
pages
421 - 428
publisher
BMJ Publishing Group
external identifiers
  • pmid:26525574
  • scopus:85011026253
  • wos:000394495800007
ISSN
1468-3288
DOI
10.1136/gutjnl-2015-309934
language
English
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yes
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34276feb-57ba-43a9-96bb-ba4c15aa68b8 (old id 8243588)
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http://www.ncbi.nlm.nih.gov/pubmed/26525574?dopt=Abstract
date added to LUP
2015-12-02 17:21:30
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2017-11-17 10:18:47
@article{34276feb-57ba-43a9-96bb-ba4c15aa68b8,
  abstract     = {Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role.},
  author       = {Westerlind, Helga and Mellander, Marie-Rose and Bresso, Francesca and Munch, Andreas and Bonfiglio, Ferdinando and Assadi, Ghazaleh and Rafter, Joseph and Hübenthal, Matthias and Lieb, Wolfgang and Källberg, Henrik and Brynedal, Boel and Padyukov, Leonid and Halfvarson, Jonas and Törkvist, Leif and Bjork, Jan and Andreasson, Anna and Agreus, Lars and Almer, Sven and Miehlke, Stephan and Madisch, Ahmed and Ohlsson, Bodil and Löfberg, Robert and Hultcrantz, Rolf and Franke, Andre and D'Amato, Mauro},
  issn         = {1468-3288},
  language     = {eng},
  pages        = {421--428},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.},
  url          = {http://dx.doi.org/10.1136/gutjnl-2015-309934},
  volume       = {66},
  year         = {2017},
}