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Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.

Westerlind, Helga; Mellander, Marie-Rose; Bresso, Francesca; Munch, Andreas; Bonfiglio, Ferdinando; Assadi, Ghazaleh; Rafter, Joseph; Hübenthal, Matthias; Lieb, Wolfgang and Källberg, Henrik, et al. (2015) In Gut
Abstract
Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role.
Please use this url to cite or link to this publication:
@article{34276feb-57ba-43a9-96bb-ba4c15aa68b8,
  abstract     = {Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in genetically predisposed individuals, but the contribution of genetic factors to CC is underinvestigated. We systematically tested immune-related genes known to impact the risk of several autoimmune diseases for their potential CC-predisposing role.},
  author       = {Westerlind, Helga and Mellander, Marie-Rose and Bresso, Francesca and Munch, Andreas and Bonfiglio, Ferdinando and Assadi, Ghazaleh and Rafter, Joseph and Hübenthal, Matthias and Lieb, Wolfgang and Källberg, Henrik and Brynedal, Boel and Padyukov, Leonid and Halfvarson, Jonas and Törkvist, Leif and Bjork, Jan and Andreasson, Anna and Agreus, Lars and Almer, Sven and Miehlke, Stephan and Madisch, Ahmed and Ohlsson, Bodil and Löfberg, Robert and Hultcrantz, Rolf and Franke, Andre and D'Amato, Mauro},
  issn         = {1468-3288},
  language     = {eng},
  month        = {11},
  publisher    = {BMJ Publishing Group},
  series       = {Gut},
  title        = {Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis.},
  url          = {http://dx.doi.org/10.1136/gutjnl-2015-309934},
  year         = {2015},
}