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Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

Magnusson, Linda LU ; Hansen, Nils LU ; Saba, Karim H LU ; Nilsson, Jenny LU ; Fioretos, Thoas LU ; Rissler, Pehr LU and Hansén Nord, Karolin LU (2017) In Journal of Pathology
Abstract

Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.

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author
organization
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type
Contribution to journal
publication status
epub
subject
keywords
Journal Article
in
Journal of Pathology
publisher
John Wiley & Sons
ISSN
0022-3417
DOI
10.1002/path.4945
language
English
LU publication?
yes
id
824f80c7-f1e8-45e0-9f3b-26d47b48219c
date added to LUP
2017-08-07 11:52:13
date last changed
2017-08-07 11:52:13
@article{824f80c7-f1e8-45e0-9f3b-26d47b48219c,
  abstract     = {<p>Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.</p>},
  author       = {Magnusson, Linda and Hansen, Nils and Saba, Karim H and Nilsson, Jenny and Fioretos, Thoas and Rissler, Pehr and Hansén Nord, Karolin},
  issn         = {0022-3417},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {07},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pathology},
  title        = {Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors},
  url          = {http://dx.doi.org/10.1002/path.4945},
  year         = {2017},
}