Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors
(2017) In Journal of Pathology 243(2). p.160-164- Abstract
Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/824f80c7-f1e8-45e0-9f3b-26d47b48219c
- author
- Magnusson, Linda LU ; Hansen, Nils LU ; Saba, Karim H LU ; Nilsson, Jenny LU ; Fioretos, Thoas LU ; Rissler, Pehr LU and Hansén Nord, Karolin LU
- organization
- publishing date
- 2017-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Journal of Pathology
- volume
- 243
- issue
- 2
- pages
- 160 - 164
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85029601896
- wos:000411123400004
- pmid:28722204
- ISSN
- 0022-3417
- DOI
- 10.1002/path.4945
- language
- English
- LU publication?
- yes
- id
- 824f80c7-f1e8-45e0-9f3b-26d47b48219c
- date added to LUP
- 2017-08-07 11:52:13
- date last changed
- 2024-02-29 19:33:05
@article{824f80c7-f1e8-45e0-9f3b-26d47b48219c, abstract = {{<p>Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.</p>}}, author = {{Magnusson, Linda and Hansen, Nils and Saba, Karim H and Nilsson, Jenny and Fioretos, Thoas and Rissler, Pehr and Hansén Nord, Karolin}}, issn = {{0022-3417}}, keywords = {{Journal Article}}, language = {{eng}}, number = {{2}}, pages = {{160--164}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Pathology}}, title = {{Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors}}, url = {{http://dx.doi.org/10.1002/path.4945}}, doi = {{10.1002/path.4945}}, volume = {{243}}, year = {{2017}}, }