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Investigation of cerebrospinal fluid flow in the cerebral aqueduct using high-resolution phase contrast measurements at 7T MRI

Markenroth Bloch, Karin LU ; Töger, Johannes LU and Ståhlberg, Freddy LU (2017) In Acta Radiologica
Abstract

Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using... (More)

Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using in-plane resolutions 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2. Feasibility criteria were defined based on scan time and spatial and temporal resolution. Results: Phantom validation of 2D-PC MR showed good accuracy. In vivo, stroke volume was −8.2 ± 4.4, −4.7 ± 2.8, −6.0 ± 3.8, and −3.7 ± 2.1 µL for 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2, respectively. The scan with 0.3 × 0.3 mm2 resolution fulfilled the feasibility criteria for a wide range of heart rates and aqueduct diameters. Conclusion: 7T MR enables non-invasive quantification of CSF flow and velocity in the cerebral aqueduct with high spatial resolution.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Cerebral aqueduct, cerebrospinal fluid, magnetic resonance imaging, pulsatile flow
in
Acta Radiologica
publisher
John Wiley & Sons
external identifiers
  • scopus:85046032788
ISSN
0284-1851
DOI
10.1177/0284185117740762
language
English
LU publication?
yes
id
828d2611-8ff8-492c-af5c-719132602e4b
date added to LUP
2018-05-16 15:30:38
date last changed
2018-05-17 03:00:02
@article{828d2611-8ff8-492c-af5c-719132602e4b,
  abstract     = {<p>Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using in-plane resolutions 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm<sup>2</sup>. Feasibility criteria were defined based on scan time and spatial and temporal resolution. Results: Phantom validation of 2D-PC MR showed good accuracy. In vivo, stroke volume was −8.2 ± 4.4, −4.7 ± 2.8, −6.0 ± 3.8, and −3.7 ± 2.1 µL for 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm<sup>2</sup>, respectively. The scan with 0.3 × 0.3 mm<sup>2</sup> resolution fulfilled the feasibility criteria for a wide range of heart rates and aqueduct diameters. Conclusion: 7T MR enables non-invasive quantification of CSF flow and velocity in the cerebral aqueduct with high spatial resolution.</p>},
  author       = {Markenroth Bloch, Karin and Töger, Johannes and Ståhlberg, Freddy},
  issn         = {0284-1851},
  keyword      = {Cerebral aqueduct,cerebrospinal fluid,magnetic resonance imaging,pulsatile flow},
  language     = {eng},
  month        = {11},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Investigation of cerebrospinal fluid flow in the cerebral aqueduct using high-resolution phase contrast measurements at 7T MRI},
  url          = {http://dx.doi.org/10.1177/0284185117740762},
  year         = {2017},
}