Immunomodulating activity of quinolones: review.
Riesbeck, Kristian LU
(2002)
In Journal of Chemotherapy
14(1).
p.3-12
- Abstract
- Fluorinated quinolones exert their bactericidal activity by inhibiting bacterial type II topoisomerases. At therapeutic concentrations, quinolones superinduce interleukin-2 (IL-2) and interferon-gamma production by mitogen-activated human peripheral blood T lymphocytes. At the molecular level, a stronger activation of the nuclear factor AP-1 ('activator protein-1') is observed in cells incubated with ciprofloxacin, resulting in enhanced cytokine gene transcription. Several cytokine and immediate early (e.g., c-fos and c-jun) mRNAs are upregulated by ciprofloxacin, possibly reflecting a mammalian stress response. In cultures with murine splenocytes, quinolones enhance IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF)... (More)
- Fluorinated quinolones exert their bactericidal activity by inhibiting bacterial type II topoisomerases. At therapeutic concentrations, quinolones superinduce interleukin-2 (IL-2) and interferon-gamma production by mitogen-activated human peripheral blood T lymphocytes. At the molecular level, a stronger activation of the nuclear factor AP-1 ('activator protein-1') is observed in cells incubated with ciprofloxacin, resulting in enhanced cytokine gene transcription. Several cytokine and immediate early (e.g., c-fos and c-jun) mRNAs are upregulated by ciprofloxacin, possibly reflecting a mammalian stress response. In cultures with murine splenocytes, quinolones enhance IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF) synthesis. The stimulation of these hematopoietic growth factors prolongs survival of mice with depressed bone marrow and prevents experimental antiphospholipid syndrome (APS). In contrast, quinolones inhibit both human and mouse monocytic IL-1 and TNF-alpha synthesis, an effect that is beneficial in rat experimental type II collagen induced arthritis and LPS-induced septic chock in mice. The intriguing immunomodulatory activities of fluoroquinolones warrant future investigations with new tailored derivatives. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/106023
- author
- Riesbeck, Kristian
LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Chemotherapy
- volume
- 14
- issue
- 1
- pages
- 3 - 12
- publisher
- Italian Society of Chemotherapy
- external identifiers
-
- wos:000174169700001
- pmid:11892896
- scopus:0036200461
- ISSN
- 1120-009X
- language
- English
- LU publication?
- yes
- id
- 82b7ae26-6118-41af-baea-b973dadf8f4e (old id 106023)
- alternative location
- http://www.jchemother.it/
- date added to LUP
- 2016-04-01 15:55:51
- date last changed
- 2022-01-28 08:06:04
@article{82b7ae26-6118-41af-baea-b973dadf8f4e,
abstract = {{Fluorinated quinolones exert their bactericidal activity by inhibiting bacterial type II topoisomerases. At therapeutic concentrations, quinolones superinduce interleukin-2 (IL-2) and interferon-gamma production by mitogen-activated human peripheral blood T lymphocytes. At the molecular level, a stronger activation of the nuclear factor AP-1 ('activator protein-1') is observed in cells incubated with ciprofloxacin, resulting in enhanced cytokine gene transcription. Several cytokine and immediate early (e.g., c-fos and c-jun) mRNAs are upregulated by ciprofloxacin, possibly reflecting a mammalian stress response. In cultures with murine splenocytes, quinolones enhance IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF) synthesis. The stimulation of these hematopoietic growth factors prolongs survival of mice with depressed bone marrow and prevents experimental antiphospholipid syndrome (APS). In contrast, quinolones inhibit both human and mouse monocytic IL-1 and TNF-alpha synthesis, an effect that is beneficial in rat experimental type II collagen induced arthritis and LPS-induced septic chock in mice. The intriguing immunomodulatory activities of fluoroquinolones warrant future investigations with new tailored derivatives.}},
author = {{Riesbeck, Kristian}},
issn = {{1120-009X}},
language = {{eng}},
number = {{1}},
pages = {{3--12}},
publisher = {{Italian Society of Chemotherapy}},
series = {{Journal of Chemotherapy}},
title = {{Immunomodulating activity of quinolones: review.}},
url = {{http://www.jchemother.it/}},
volume = {{14}},
year = {{2002}},
}