Time to Blood Culture Positivity: An Independent Predictor of Mortality in Streptococcus Pyogenes Bacteremia
(2022) In Open Forum Infectious Diseases 9(6).- Abstract
- Background
Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.
Methods
This retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified through the laboratory database between 2015 and 2018, in the Region of Skåne, Sweden. Correlations between TTP and outcomes were investigated. Primary outcome was death within 30 days, and secondary outcomes were presence of sepsis or disease deterioration within the first 48 hours.
Results
A total of 347 episodes of S... (More) - Background
Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.
Methods
This retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified through the laboratory database between 2015 and 2018, in the Region of Skåne, Sweden. Correlations between TTP and outcomes were investigated. Primary outcome was death within 30 days, and secondary outcomes were presence of sepsis or disease deterioration within the first 48 hours.
Results
A total of 347 episodes of S pyogenes bacteremia were identified, of which 61 were excluded, resulting in 286 included episodes. Median TTP was 10.4 (interquartile range, 8.4–11.4) hours. Thirty-day mortality was 10%. Median TTP was shorter in patients who died within 30 days compared to survivors (8.6 vs 10.4 hours; P < .001). In a multivariable logistic regression, shorter TTP was associated with 30-day mortality when adjusting for age, Charlson Comorbidity Index, and focus of infection (odds ratio, 3.7 [95% confidence interval, 1.2–11.3]; P = .02). There was no statistically significant difference in TTP between patients with sepsis within 48 hours and those who did not have sepsis. Additionally, there was no statistically significant difference in TTP between patients with disease deterioration compared to those who did not deteriorate.
Conclusions
Knowledge on TTP might be a tool to determine the prognosis of a given patient with S pyogenes bacteremia. (Less) - Abstract (Swedish)
- Background
Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.
Methods
This retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified through the laboratory database between 2015 and 2018, in the Region of Skåne, Sweden. Correlations between TTP and outcomes were investigated. Primary outcome was death within 30 days, and secondary outcomes were presence of sepsis or disease deterioration within the first 48 hours.
Results
A total of 347 episodes... (More) - Background
Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.
Methods
This retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified through the laboratory database between 2015 and 2018, in the Region of Skåne, Sweden. Correlations between TTP and outcomes were investigated. Primary outcome was death within 30 days, and secondary outcomes were presence of sepsis or disease deterioration within the first 48 hours.
Results
A total of 347 episodes of S pyogenes bacteremia were identified, of which 61 were excluded, resulting in 286 included episodes. Median TTP was 10.4 (interquartile range, 8.4–11.4) hours. Thirty-day mortality was 10%. Median TTP was shorter in patients who died within 30 days compared to survivors (8.6 vs 10.4 hours; P < .001). In a multivariable logistic regression, shorter TTP was associated with 30-day mortality when adjusting for age, Charlson Comorbidity Index, and focus of infection (odds ratio, 3.7 [95% confidence interval, 1.2–11.3]; P = .02). There was no statistically significant difference in TTP between patients with sepsis within 48 hours and those who did not have sepsis. Additionally, there was no statistically significant difference in TTP between patients with disease deterioration compared to those who did not deteriorate.
Conclusions
Knowledge on TTP might be a tool to determine the prognosis of a given patient with S pyogenes bacteremia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/82e83533-da0f-42e5-8611-3edc48f4aaee
- author
- Bläckberg, Anna LU ; Svedevall, Stina ; Lundberg, Katrina LU ; Nilson, Bo LU ; Kahn, Fredrik LU and Rasmussen, Magnus LU
- organization
- publishing date
- 2022-05-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Open Forum Infectious Diseases
- volume
- 9
- issue
- 6
- article number
- ofac163
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85132980845
- pmid:35615297
- ISSN
- 2328-8957
- DOI
- 10.1093/ofid/ofac163
- language
- English
- LU publication?
- yes
- id
- 82e83533-da0f-42e5-8611-3edc48f4aaee
- date added to LUP
- 2023-08-08 16:18:47
- date last changed
- 2023-08-10 03:00:03
@article{82e83533-da0f-42e5-8611-3edc48f4aaee, abstract = {{Background<br/>Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the association between TTP and outcome in S pyogenes bacteremia.<br/>Methods<br/>This retrospective observational cohort study comprised adults with S pyogenes bacteremia, identified through the laboratory database between 2015 and 2018, in the Region of Skåne, Sweden. Correlations between TTP and outcomes were investigated. Primary outcome was death within 30 days, and secondary outcomes were presence of sepsis or disease deterioration within the first 48 hours.<br/>Results<br/>A total of 347 episodes of S pyogenes bacteremia were identified, of which 61 were excluded, resulting in 286 included episodes. Median TTP was 10.4 (interquartile range, 8.4–11.4) hours. Thirty-day mortality was 10%. Median TTP was shorter in patients who died within 30 days compared to survivors (8.6 vs 10.4 hours; P < .001). In a multivariable logistic regression, shorter TTP was associated with 30-day mortality when adjusting for age, Charlson Comorbidity Index, and focus of infection (odds ratio, 3.7 [95% confidence interval, 1.2–11.3]; P = .02). There was no statistically significant difference in TTP between patients with sepsis within 48 hours and those who did not have sepsis. Additionally, there was no statistically significant difference in TTP between patients with disease deterioration compared to those who did not deteriorate.<br/>Conclusions<br/>Knowledge on TTP might be a tool to determine the prognosis of a given patient with S pyogenes bacteremia.}}, author = {{Bläckberg, Anna and Svedevall, Stina and Lundberg, Katrina and Nilson, Bo and Kahn, Fredrik and Rasmussen, Magnus}}, issn = {{2328-8957}}, language = {{eng}}, month = {{05}}, number = {{6}}, publisher = {{Oxford University Press}}, series = {{Open Forum Infectious Diseases}}, title = {{Time to Blood Culture Positivity: An Independent Predictor of Mortality in Streptococcus Pyogenes Bacteremia}}, url = {{http://dx.doi.org/10.1093/ofid/ofac163}}, doi = {{10.1093/ofid/ofac163}}, volume = {{9}}, year = {{2022}}, }