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Influence of PLDLA on the Rheological Properties of Regenerated Silk Fibroin-Based Gels

Antunes, Bianca Sabino Leocádio ; Komatsu, Daniel ; Soto Garcia, Pâmela LU ; Dicko, Cedric LU orcid and Duek, Eliana Aparecida de Rezende (2026) In Biomacromolecules 27(2). p.1187-1195
Abstract

Regenerated silk fibroin (RSF), obtained from the silk fibers of the species Bombyx mori, is a promising biomaterial due to its excellent mechanical and biological properties, as well as presenting versatility for applications in tissue engineering. This is particularly evident through the development of scaffolds via the 3D printing process. The viscosity of RSF solutions can be controlled by adding other synthetic polymers, thereby ensuring improved mechanical and rheological properties and enhanced quality of printed structures. The objective of this study is to investigate the rheological properties of gels based on RSF and PLDLA (poly(l-co-d,l-lactic acid)). The study involved the synthesis of PLDLA and the extraction of RSF from... (More)

Regenerated silk fibroin (RSF), obtained from the silk fibers of the species Bombyx mori, is a promising biomaterial due to its excellent mechanical and biological properties, as well as presenting versatility for applications in tissue engineering. This is particularly evident through the development of scaffolds via the 3D printing process. The viscosity of RSF solutions can be controlled by adding other synthetic polymers, thereby ensuring improved mechanical and rheological properties and enhanced quality of printed structures. The objective of this study is to investigate the rheological properties of gels based on RSF and PLDLA (poly(l-co-d,l-lactic acid)). The study involved the synthesis of PLDLA and the extraction of RSF from the silk threads of B. mori. Subsequently, RSF-PLDLA solutions in formic acid were prepared with varying concentrations, and subsequently subjected to rheological tests under steady-state and oscillatory regimes.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomacromolecules
volume
27
issue
2
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:105029629936
  • pmid:41576402
ISSN
1526-4602
DOI
10.1021/acs.biomac.5c01312
language
English
LU publication?
yes
id
836a7dd4-07c4-4574-8cf2-3fb0e7e6b919
date added to LUP
2026-03-02 15:53:27
date last changed
2026-06-09 05:25:20
@article{836a7dd4-07c4-4574-8cf2-3fb0e7e6b919,
  abstract     = {{<p>Regenerated silk fibroin (RSF), obtained from the silk fibers of the species Bombyx mori, is a promising biomaterial due to its excellent mechanical and biological properties, as well as presenting versatility for applications in tissue engineering. This is particularly evident through the development of scaffolds via the 3D printing process. The viscosity of RSF solutions can be controlled by adding other synthetic polymers, thereby ensuring improved mechanical and rheological properties and enhanced quality of printed structures. The objective of this study is to investigate the rheological properties of gels based on RSF and PLDLA (poly(l-co-d,l-lactic acid)). The study involved the synthesis of PLDLA and the extraction of RSF from the silk threads of B. mori. Subsequently, RSF-PLDLA solutions in formic acid were prepared with varying concentrations, and subsequently subjected to rheological tests under steady-state and oscillatory regimes.</p>}},
  author       = {{Antunes, Bianca Sabino Leocádio and Komatsu, Daniel and Soto Garcia, Pâmela and Dicko, Cedric and Duek, Eliana Aparecida de Rezende}},
  issn         = {{1526-4602}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1187--1195}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Biomacromolecules}},
  title        = {{Influence of PLDLA on the Rheological Properties of Regenerated Silk Fibroin-Based Gels}},
  url          = {{http://dx.doi.org/10.1021/acs.biomac.5c01312}},
  doi          = {{10.1021/acs.biomac.5c01312}},
  volume       = {{27}},
  year         = {{2026}},
}