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Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS)

Storch, Alexander; Schneider, Christine B.; Klingelhoefer, Lisa; Odin, Per LU ; Fuchs, Gerd; Jost, Wolfgang H.; Martinez-Martin, Pablo; Koch, Rainer; Reichmann, Heinz and Chaudhuri, K. Ray, et al. (2015) In Journal of Neural Transmission 122(12). p.1673-1684
Abstract
Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. Delta NMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 +/- A 9.7... (More)
Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. Delta NMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 +/- A 9.7 years) with mean total NMSS score in On state of 41.5 +/- A 37.6 and in Off state of 75.6 +/- A 42.3 (P < 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and Delta NMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression. (Less)
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Contribution to journal
publication status
published
subject
keywords
of life (QoL), Quality, Parkinson's disease, Autonomic dysfunction, Apathy, Depression, Motor complications, Non-motor fluctuations, Non-motor symptoms
in
Journal of Neural Transmission
volume
122
issue
12
pages
1673 - 1684
publisher
Springer
external identifiers
  • wos:000364975300006
  • scopus:84947488327
ISSN
0300-9564
DOI
10.1007/s00702-015-1437-x
language
English
LU publication?
yes
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e2bf6a1c-bbfa-4a95-8a4b-30ce546af3b7 (old id 8370676)
date added to LUP
2016-01-04 07:05:57
date last changed
2017-10-22 04:05:22
@article{e2bf6a1c-bbfa-4a95-8a4b-30ce546af3b7,
  abstract     = {Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. Delta NMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 +/- A 9.7 years) with mean total NMSS score in On state of 41.5 +/- A 37.6 and in Off state of 75.6 +/- A 42.3 (P &lt; 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and Delta NMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression.},
  author       = {Storch, Alexander and Schneider, Christine B. and Klingelhoefer, Lisa and Odin, Per and Fuchs, Gerd and Jost, Wolfgang H. and Martinez-Martin, Pablo and Koch, Rainer and Reichmann, Heinz and Chaudhuri, K. Ray and Ebersbach, Georg},
  issn         = {0300-9564},
  keyword      = {of life (QoL),Quality,Parkinson's disease,Autonomic dysfunction,Apathy,Depression,Motor complications,Non-motor fluctuations,Non-motor symptoms},
  language     = {eng},
  number       = {12},
  pages        = {1673--1684},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS)},
  url          = {http://dx.doi.org/10.1007/s00702-015-1437-x},
  volume       = {122},
  year         = {2015},
}