Detection by near-infrared spectroscopy of large lipid cores at culprit sites in patients with non-st-segment elevation myocardial infarction and unstable angina
(2015) In Catheterization and Cardiovascular Interventions 86(6). p.1014-1021- Abstract
- ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are characterized by a similarly large lipid burden is unknown. MethodsWe studied 81 non-STEMI and UA patients undergoing culprit vessel NIRS imaging before stenting. Culprit segments were compared to all nonoverlapping 10-mm nonculprit segments for maxLCBI(4mm). Culprit segments in non-STEMI and UA were compared for the frequency of maxLCBI(4mm)400.... (More)
- ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are characterized by a similarly large lipid burden is unknown. MethodsWe studied 81 non-STEMI and UA patients undergoing culprit vessel NIRS imaging before stenting. Culprit segments were compared to all nonoverlapping 10-mm nonculprit segments for maxLCBI(4mm). Culprit segments in non-STEMI and UA were compared for the frequency of maxLCBI(4mm)400. ResultsAmong 81 patients (53.1% non-STEMI, 46.9% UA), non-STEMI culprit segments had a 3.4-fold greater maxLCBI(4mm) than nonculprits (448229 vs 132 +/- 154, P<0.001) and UA culprit segments had a 2.6-fold higher maxLCBI(4mm) than nonculprits (381 +/- 239 vs 146 +/- 175, P<0.001). NIRS detected a maxLCBI(4mm)400 in 63.6% of culprit segments in NSTEMI and in 38.5% of culprit segments in UA (P=0.02). Against a background of nonculprit segments, maxLCBI(4mm)400 had a sensitivity of 63.6% and specificity of 94.0% for culprit segments in NSTEMI and a sensitivity of 38.5% and specificity of 89.8% for culprit segments in UA. ConclusionsLarge lipid cores similar to those recently detected by NIRS at STEMI culprit sites were frequently observed at culprit sites in patients with non-STEMI and UA. These findings support ongoing prospective trials designed to determine if NIRS can provide site-specific prediction of future acute coronary events. (c) 2014 Wiley Periodicals, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8377511
- author
- Madder, Ryan D.
; Husaini, Mustafa
; Davis, Alan T.
; VanOosterhout, Stacie
; Harnek, Jan
LU
; Götberg, Matthias
LU
and Erlinge, David
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- acute coronary syndrome, lipid core plaque, near-infrared spectroscopy
- in
- Catheterization and Cardiovascular Interventions
- volume
- 86
- issue
- 6
- pages
- 1014 - 1021
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000364650800017
- scopus:84946545719
- pmid:25418711
- ISSN
- 1522-1946
- DOI
- 10.1002/ccd.25754
- language
- English
- LU publication?
- yes
- id
- 49d35fba-bde9-4dbc-b53b-d9130dda8eb0 (old id 8377511)
- date added to LUP
- 2016-04-01 14:58:38
- date last changed
- 2022-03-22 02:47:11
@article{49d35fba-bde9-4dbc-b53b-d9130dda8eb0, abstract = {{ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are characterized by a similarly large lipid burden is unknown. MethodsWe studied 81 non-STEMI and UA patients undergoing culprit vessel NIRS imaging before stenting. Culprit segments were compared to all nonoverlapping 10-mm nonculprit segments for maxLCBI(4mm). Culprit segments in non-STEMI and UA were compared for the frequency of maxLCBI(4mm)400. ResultsAmong 81 patients (53.1% non-STEMI, 46.9% UA), non-STEMI culprit segments had a 3.4-fold greater maxLCBI(4mm) than nonculprits (448229 vs 132 +/- 154, P<0.001) and UA culprit segments had a 2.6-fold higher maxLCBI(4mm) than nonculprits (381 +/- 239 vs 146 +/- 175, P<0.001). NIRS detected a maxLCBI(4mm)400 in 63.6% of culprit segments in NSTEMI and in 38.5% of culprit segments in UA (P=0.02). Against a background of nonculprit segments, maxLCBI(4mm)400 had a sensitivity of 63.6% and specificity of 94.0% for culprit segments in NSTEMI and a sensitivity of 38.5% and specificity of 89.8% for culprit segments in UA. ConclusionsLarge lipid cores similar to those recently detected by NIRS at STEMI culprit sites were frequently observed at culprit sites in patients with non-STEMI and UA. These findings support ongoing prospective trials designed to determine if NIRS can provide site-specific prediction of future acute coronary events. (c) 2014 Wiley Periodicals, Inc.}}, author = {{Madder, Ryan D. and Husaini, Mustafa and Davis, Alan T. and VanOosterhout, Stacie and Harnek, Jan and Götberg, Matthias and Erlinge, David}}, issn = {{1522-1946}}, keywords = {{acute coronary syndrome; lipid core plaque; near-infrared spectroscopy}}, language = {{eng}}, number = {{6}}, pages = {{1014--1021}}, publisher = {{Wiley-Blackwell}}, series = {{Catheterization and Cardiovascular Interventions}}, title = {{Detection by near-infrared spectroscopy of large lipid cores at culprit sites in patients with non-st-segment elevation myocardial infarction and unstable angina}}, url = {{http://dx.doi.org/10.1002/ccd.25754}}, doi = {{10.1002/ccd.25754}}, volume = {{86}}, year = {{2015}}, }