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Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect : A theoretical study

Gunther, Jacqueline; Walther, Andreas LU ; Rippe, Lars LU ; Kröll, Stefan LU and Andersson-Engels, Stefan LU (2018) In Journal of Biomedical Optics 23(7).
Abstract

Biological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present a theoretical study of a system that combines acousto-optical tomography and slow light spectral filters created using spectral hole burning methods. Using Monte Carlo simulations, a model to obtain the contrast-to-noise ratio (CNR) deep in biological tissue was developed. The simulations show a CNR > 1 for imaging depths of ∼5 cm in a... (More)

Biological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present a theoretical study of a system that combines acousto-optical tomography and slow light spectral filters created using spectral hole burning methods. Using Monte Carlo simulations, a model to obtain the contrast-to-noise ratio (CNR) deep in biological tissue was developed. The simulations show a CNR > 1 for imaging depths of ∼5 cm in a reflection mode setup, as well as, imaging through ∼12 cm in transmission mode setups. These results are promising and form the basis for future experimental studies.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
acousto-optical tomography, Monte Carlo, spectral hole burning, ultrasound modulation
in
Journal of Biomedical Optics
volume
23
issue
7
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • scopus:85046079996
ISSN
1083-3668
DOI
10.1117/1.JBO.23.7.071209
language
English
LU publication?
yes
id
83a4d246-da44-4f78-9128-df989f55a136
date added to LUP
2018-05-07 13:43:32
date last changed
2019-02-20 11:16:30
@article{83a4d246-da44-4f78-9128-df989f55a136,
  abstract     = {<p>Biological tissue is a highly scattering medium that prevents deep imaging of light. For medical applications, optical imaging offers a molecular sensitivity that would be beneficial for diagnosing and monitoring of diseases. Acousto-optical tomography has the molecular sensitivity of optical imaging with the resolution of ultrasound and has the potential for deep tissue imaging. Here, we present a theoretical study of a system that combines acousto-optical tomography and slow light spectral filters created using spectral hole burning methods. Using Monte Carlo simulations, a model to obtain the contrast-to-noise ratio (CNR) deep in biological tissue was developed. The simulations show a CNR &gt; 1 for imaging depths of ∼5 cm in a reflection mode setup, as well as, imaging through ∼12 cm in transmission mode setups. These results are promising and form the basis for future experimental studies.</p>},
  articleno    = {071209},
  author       = {Gunther, Jacqueline and Walther, Andreas and Rippe, Lars and Kröll, Stefan and Andersson-Engels, Stefan},
  issn         = {1083-3668},
  keyword      = {acousto-optical tomography,Monte Carlo,spectral hole burning,ultrasound modulation},
  language     = {eng},
  month        = {07},
  number       = {7},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {Deep tissue imaging with acousto-optical tomography and spectral hole burning with slow light effect : A theoretical study},
  url          = {http://dx.doi.org/10.1117/1.JBO.23.7.071209},
  volume       = {23},
  year         = {2018},
}