Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus
Westholm, Efraim LU ; Wendt, Anna LU and Eliasson, Lena LU
(2021)
In Clinical Medicine Insights: Endocrinology and Diabetes
14.
p.1-7
- Abstract
- Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to aberrant luminal fluid secretions in organs such as the lungs and pancreas. How dysfunctional CFTR leads to CFRD is still under debate. Both intrinsic effects of dysfunctional CFTR in hormone secreting cells of the islets and effects of exocrine damage have been proposed. In the current review, we discuss these non-mutually exclusive hypotheses with a special focus on how dysfunctional CFTR in endocrine cells may contribute to an altered glucose homeostasis. We outline the proposed role of CFTR in the molecular... (More)
- Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to aberrant luminal fluid secretions in organs such as the lungs and pancreas. How dysfunctional CFTR leads to CFRD is still under debate. Both intrinsic effects of dysfunctional CFTR in hormone secreting cells of the islets and effects of exocrine damage have been proposed. In the current review, we discuss these non-mutually exclusive hypotheses with a special focus on how dysfunctional CFTR in endocrine cells may contribute to an altered glucose homeostasis. We outline the proposed role of CFTR in the molecular pathways of β-cell insulin secretion and α-cell glucagon secretion, and touch upon the importance of the exocrine pancreas and intra-pancreatic crosstalk for proper islet function (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/83aa37d0-daa7-47ab-87fd-075b8e888436
- author
- Westholm, Efraim
LU
; Wendt, Anna
LU
and Eliasson, Lena
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Medicine Insights: Endocrinology and Diabetes
- volume
- 14
- pages
- 1 - 7
- publisher
- SAGE Publications
- external identifiers
-
- pmid:34345195
- scopus:85110032547
- ISSN
- 1179-5514
- DOI
- 10.1177/11795514211031204
- language
- English
- LU publication?
- yes
- id
- 83aa37d0-daa7-47ab-87fd-075b8e888436
- date added to LUP
- 2022-01-24 13:33:27
- date last changed
- 2022-04-27 07:17:25
@article{83aa37d0-daa7-47ab-87fd-075b8e888436,
abstract = {{Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to aberrant luminal fluid secretions in organs such as the lungs and pancreas. How dysfunctional CFTR leads to CFRD is still under debate. Both intrinsic effects of dysfunctional CFTR in hormone secreting cells of the islets and effects of exocrine damage have been proposed. In the current review, we discuss these non-mutually exclusive hypotheses with a special focus on how dysfunctional CFTR in endocrine cells may contribute to an altered glucose homeostasis. We outline the proposed role of CFTR in the molecular pathways of β-cell insulin secretion and α-cell glucagon secretion, and touch upon the importance of the exocrine pancreas and intra-pancreatic crosstalk for proper islet function}},
author = {{Westholm, Efraim and Wendt, Anna and Eliasson, Lena}},
issn = {{1179-5514}},
language = {{eng}},
pages = {{1--7}},
publisher = {{SAGE Publications}},
series = {{Clinical Medicine Insights: Endocrinology and Diabetes}},
title = {{Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus}},
url = {{http://dx.doi.org/10.1177/11795514211031204}},
doi = {{10.1177/11795514211031204}},
volume = {{14}},
year = {{2021}},
}