Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Brain-derived neurotrophic factor, neutrophils and cysteinyl leukotriene receptor 1 as potential prognostic biomarkers for patients with colon cancer

Mehrabi, Syrina F. LU ; Ghatak, Souvik LU ; Mehdawi, Lubna M. LU ; Topi, Geriolda LU ; Satapathy, Shakti Ranjan LU and Sjölander, Anita LU (2021) In Cancers 13(21).
Abstract

The tumor microenvironment has been recognized as a complex network in which immune cells play an important role in cancer progression. We found significantly higher CD66b neutrophil expression in tumor tissue than in matched normal mucosa in the Malmö colon cancer (CC) cohort and poorer survival of stage I-III patients with high CD66b expression. Additionally, mice lacking CysLT1 R expression (cysltr1−/− ) produce less brain-derived neurotrophic factor (BDNF) compared to WT mice and Montelukast (a CysLT1 R antagonist)-treated mice also reduced BDNF expression in a mouse xenograft model with human SW480 CC cells. CD66b and BDNF expression was significantly higher in patient tumor tissues than in the... (More)

The tumor microenvironment has been recognized as a complex network in which immune cells play an important role in cancer progression. We found significantly higher CD66b neutrophil expression in tumor tissue than in matched normal mucosa in the Malmö colon cancer (CC) cohort and poorer survival of stage I-III patients with high CD66b expression. Additionally, mice lacking CysLT1 R expression (cysltr1−/− ) produce less brain-derived neurotrophic factor (BDNF) compared to WT mice and Montelukast (a CysLT1 R antagonist)-treated mice also reduced BDNF expression in a mouse xenograft model with human SW480 CC cells. CD66b and BDNF expression was significantly higher in patient tumor tissues than in the matched normal mucosa. The univariate Cox PH analysis yielded CD66b and BDNF as an independent predictor of overall survival, which was also found in the public TCGA-COAD dataset. We also discovered a strong positive correlation between CD66b, BDNF and CysLT1 R expression in the Malmö CC cohort and in the TCGA-COAD dataset. Our data suggest that CD66b/BDNF/CysLT1 R expression as a prognostic combined biomarker signature for CC patients.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BDNF, Colon cancer, CysLT, LTD, Montelukast, Neutrophils
in
Cancers
volume
13
issue
21
article number
5520
publisher
MDPI AG
external identifiers
  • scopus:85118348629
  • pmid:34771682
ISSN
2072-6694
DOI
10.3390/cancers13215520
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
id
83b8ef4f-8433-473a-aa1e-f05ef0a92068
date added to LUP
2021-11-26 12:03:55
date last changed
2024-06-15 21:32:12
@article{83b8ef4f-8433-473a-aa1e-f05ef0a92068,
  abstract     = {{<p>The tumor microenvironment has been recognized as a complex network in which immune cells play an important role in cancer progression. We found significantly higher CD66b neutrophil expression in tumor tissue than in matched normal mucosa in the Malmö colon cancer (CC) cohort and poorer survival of stage I-III patients with high CD66b expression. Additionally, mice lacking CysLT<sub>1</sub> R expression (cysltr1<sup>−/−</sup> ) produce less brain-derived neurotrophic factor (BDNF) compared to WT mice and Montelukast (a CysLT<sub>1</sub> R antagonist)-treated mice also reduced BDNF expression in a mouse xenograft model with human SW480 CC cells. CD66b and BDNF expression was significantly higher in patient tumor tissues than in the matched normal mucosa. The univariate Cox PH analysis yielded CD66b and BDNF as an independent predictor of overall survival, which was also found in the public TCGA-COAD dataset. We also discovered a strong positive correlation between CD66b, BDNF and CysLT<sub>1</sub> R expression in the Malmö CC cohort and in the TCGA-COAD dataset. Our data suggest that CD66b/BDNF/CysLT<sub>1</sub> R expression as a prognostic combined biomarker signature for CC patients.</p>}},
  author       = {{Mehrabi, Syrina F. and Ghatak, Souvik and Mehdawi, Lubna M. and Topi, Geriolda and Satapathy, Shakti Ranjan and Sjölander, Anita}},
  issn         = {{2072-6694}},
  keywords     = {{BDNF; Colon cancer; CysLT; LTD; Montelukast; Neutrophils}},
  language     = {{eng}},
  number       = {{21}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Brain-derived neurotrophic factor, neutrophils and cysteinyl leukotriene receptor 1 as potential prognostic biomarkers for patients with colon cancer}},
  url          = {{http://dx.doi.org/10.3390/cancers13215520}},
  doi          = {{10.3390/cancers13215520}},
  volume       = {{13}},
  year         = {{2021}},
}