Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Risk and prognosis of colorectal cancer following bacteraemia with Streptococcus bovis-Streptococcus equinus complex : A Swedish nationwide retrospective cohort study

Öberg, Jonas LU orcid ; Buchwald, Pamela LU ; Nilsson, Anton LU ; Nilson, Bo LU orcid and Inghammar, Malin LU (2025) In Epidemiology and Infection 154.
Abstract

There is a positive association between bacteraemia with Streptococcus bovis-Streptococcus equinus complex (SBSEC) and colorectal cancer (CRC). However, the relationship between the timing of SBSEC bacteraemia and CRC is not well-established. Associations with other gastrointestinal cancers have also been suggested. Using national registries, we retrospectively examined the incidence of CRC and other gastrointestinal cancers after SBSEC-bacteraemia in Sweden 2010-2019, and analysed the timing, characteristics, and prognosis of diagnosed CRC. Individuals with SBSEC-bacteraemia were matched to randomly selected controls from the general population at a 1:10 ratio. Cox-regression determined CRC hazard ratios (HR). In total, 908 individuals... (More)

There is a positive association between bacteraemia with Streptococcus bovis-Streptococcus equinus complex (SBSEC) and colorectal cancer (CRC). However, the relationship between the timing of SBSEC bacteraemia and CRC is not well-established. Associations with other gastrointestinal cancers have also been suggested. Using national registries, we retrospectively examined the incidence of CRC and other gastrointestinal cancers after SBSEC-bacteraemia in Sweden 2010-2019, and analysed the timing, characteristics, and prognosis of diagnosed CRC. Individuals with SBSEC-bacteraemia were matched to randomly selected controls from the general population at a 1:10 ratio. Cox-regression determined CRC hazard ratios (HR). In total, 908 individuals with SBSEC-bacteraemia were identified and 9,080 controls, of whom 75/908 (8.3%) and 168/9080 (1.9%) respectively had previously diagnosed CRC (p < 0.01). During follow-up of individuals without previous CRC, CRC was diagnosed in 45/833 (5.4%) individuals with SBSEC and 114/8912 (1.3%) controls (p < 0.01). The HR of CRC diagnosis for SBSEC was 10.3 (95% CI 6.7-15.8) overall and 19.8 (95% CI 11.1-35.3) during the first year of follow-up. In conclusion, there was an increased incidence of CRC, and most were diagnosed within the first year. Neither the tumour location, -stage, or -grade of diagnosed CRC nor the rates of other gastrointestinal cancers differed significantly.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Sweden/epidemiology, Male, Female, Retrospective Studies, Bacteremia/complications, Aged, Middle Aged, Streptococcal Infections/epidemiology, Prognosis, Streptococcus bovis, Colorectal Neoplasms/epidemiology, Incidence, Risk Factors, Aged, 80 and over, Adult
in
Epidemiology and Infection
volume
154
article number
e2
publisher
Cambridge University Press
external identifiers
  • pmid:41449806
  • scopus:105025885413
ISSN
0950-2688
DOI
10.1017/S0950268825100836
project
Streptococcus bovis och gastrointestinal cancer: Epidemiologi, etiologi och diagnostik
language
English
LU publication?
yes
id
841288c6-224a-4dcb-b7f9-48b07fb6e1e3
date added to LUP
2026-01-07 09:51:55
date last changed
2026-06-11 23:59:21
@article{841288c6-224a-4dcb-b7f9-48b07fb6e1e3,
  abstract     = {{<p>There is a positive association between bacteraemia with Streptococcus bovis-Streptococcus equinus complex (SBSEC) and colorectal cancer (CRC). However, the relationship between the timing of SBSEC bacteraemia and CRC is not well-established. Associations with other gastrointestinal cancers have also been suggested. Using national registries, we retrospectively examined the incidence of CRC and other gastrointestinal cancers after SBSEC-bacteraemia in Sweden 2010-2019, and analysed the timing, characteristics, and prognosis of diagnosed CRC. Individuals with SBSEC-bacteraemia were matched to randomly selected controls from the general population at a 1:10 ratio. Cox-regression determined CRC hazard ratios (HR). In total, 908 individuals with SBSEC-bacteraemia were identified and 9,080 controls, of whom 75/908 (8.3%) and 168/9080 (1.9%) respectively had previously diagnosed CRC (p &lt; 0.01). During follow-up of individuals without previous CRC, CRC was diagnosed in 45/833 (5.4%) individuals with SBSEC and 114/8912 (1.3%) controls (p &lt; 0.01). The HR of CRC diagnosis for SBSEC was 10.3 (95% CI 6.7-15.8) overall and 19.8 (95% CI 11.1-35.3) during the first year of follow-up. In conclusion, there was an increased incidence of CRC, and most were diagnosed within the first year. Neither the tumour location, -stage, or -grade of diagnosed CRC nor the rates of other gastrointestinal cancers differed significantly.</p>}},
  author       = {{Öberg, Jonas and Buchwald, Pamela and Nilsson, Anton and Nilson, Bo and Inghammar, Malin}},
  issn         = {{0950-2688}},
  keywords     = {{Humans; Sweden/epidemiology; Male; Female; Retrospective Studies; Bacteremia/complications; Aged; Middle Aged; Streptococcal Infections/epidemiology; Prognosis; Streptococcus bovis; Colorectal Neoplasms/epidemiology; Incidence; Risk Factors; Aged, 80 and over; Adult}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Cambridge University Press}},
  series       = {{Epidemiology and Infection}},
  title        = {{Risk and prognosis of colorectal cancer following bacteraemia with Streptococcus bovis-Streptococcus equinus complex : A Swedish nationwide retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1017/S0950268825100836}},
  doi          = {{10.1017/S0950268825100836}},
  volume       = {{154}},
  year         = {{2025}},
}