Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Understanding the role of diabetes in the osteoarthritis disease and treatment process : A study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort

Dell'Isola, Andrea LU ; Vinblad, Johanna ; Lohmander, Stefan LU orcid ; Svensson, Ann Marie ; Turkiewicz, Aleksandra LU ; Franzén, Stefan ; Nauclér, Emma ; W-Dahl, A. LU ; Abbott, Allan and Dahlberg, L. LU , et al. (2019) In BMJ Open 9(12).
Abstract

Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients' health and quality of life. However, little is known on the role of diabetes in determining the outcome of non-surgical and surgical management of OA, and at the same time, how different OA interventions may affect diabetes control. Thus, the overall aim of this project is to explore (1) the impact of... (More)

Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients' health and quality of life. However, little is known on the role of diabetes in determining the outcome of non-surgical and surgical management of OA, and at the same time, how different OA interventions may affect diabetes control. Thus, the overall aim of this project is to explore (1) the impact of diabetes on the outcome of non-surgical and surgical OA treatments and (2) the impact of non-surgical and surgical OA treatments on diabetes control. Methods and analysis The study cohort is based on prospectively ascertained register data on a national level in Sweden. Data from OA patients who received a first-line non-surgical intervention and are registered in the National Quality Register for Better Management of Patients with Osteoarthritis will be merged with data from the Swedish Knee and Hip Arthroplasty Registers and the National Diabetes Register. Additional variables regarding patients' use of prescribed drugs, comorbidities, socioeconomic status and cause of death will be obtained through other national health and population data registers. The linkage will be performed on an individual level using unique personal identity numbers. Ethics and dissemination This study received ethical approval (2019-02570) from the Swedish Ethical Review Authority. Results from this cohort will be submitted to peer-reviewed scientific journals and reported at the leading national and international meetings in the field.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort, exercise, general diabetes, osteoarthritis, register, surgery
in
BMJ Open
volume
9
issue
12
article number
e032923
publisher
BMJ Publishing Group
external identifiers
  • pmid:31852705
  • scopus:85077057926
ISSN
2044-6055
DOI
10.1136/bmjopen-2019-032923
language
English
LU publication?
yes
additional info
Publisher Copyright: © © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
id
841cd811-11bc-4790-8676-562e51c19804
date added to LUP
2024-09-15 16:37:35
date last changed
2024-09-16 08:27:43
@article{841cd811-11bc-4790-8676-562e51c19804,
  abstract     = {{<p>Introduction Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide. Metabolic comorbidities such as type II diabetes occur with a higher rate in people with OA than in the general population. Several factors including obesity, hyperglycaemia toxicity and physical inactivity have been suggested as potential links between diabetes and OA, and have been shown to negatively impact patients' health and quality of life. However, little is known on the role of diabetes in determining the outcome of non-surgical and surgical management of OA, and at the same time, how different OA interventions may affect diabetes control. Thus, the overall aim of this project is to explore (1) the impact of diabetes on the outcome of non-surgical and surgical OA treatments and (2) the impact of non-surgical and surgical OA treatments on diabetes control. Methods and analysis The study cohort is based on prospectively ascertained register data on a national level in Sweden. Data from OA patients who received a first-line non-surgical intervention and are registered in the National Quality Register for Better Management of Patients with Osteoarthritis will be merged with data from the Swedish Knee and Hip Arthroplasty Registers and the National Diabetes Register. Additional variables regarding patients' use of prescribed drugs, comorbidities, socioeconomic status and cause of death will be obtained through other national health and population data registers. The linkage will be performed on an individual level using unique personal identity numbers. Ethics and dissemination This study received ethical approval (2019-02570) from the Swedish Ethical Review Authority. Results from this cohort will be submitted to peer-reviewed scientific journals and reported at the leading national and international meetings in the field.</p>}},
  author       = {{Dell'Isola, Andrea and Vinblad, Johanna and Lohmander, Stefan and Svensson, Ann Marie and Turkiewicz, Aleksandra and Franzén, Stefan and Nauclér, Emma and W-Dahl, A. and Abbott, Allan and Dahlberg, L. and Rolfson, Ola and Englund, Martin}},
  issn         = {{2044-6055}},
  keywords     = {{cohort; exercise; general diabetes; osteoarthritis; register; surgery}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{12}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Understanding the role of diabetes in the osteoarthritis disease and treatment process : A study protocol for the Swedish Osteoarthritis and Diabetes (SOAD) cohort}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2019-032923}},
  doi          = {{10.1136/bmjopen-2019-032923}},
  volume       = {{9}},
  year         = {{2019}},
}