Assessing Tissue Hydration Dynamics Based on Water/Fat Separated MRI
(2023) In Journal of Magnetic Resonance Imaging 58(2). p.652-660- Abstract
Background: Optimal fluid status is an important issue in hemodialysis. Clinical evaluation of volume status and different diagnostic tools are used to determine hydration status in these patients. However, there is still no accurate method for this assessment. Purpose: To propose and evaluate relative lean water signal (LWSrel) as a water–fat MRI-based tissue hydration measurement. Study Type: Prospective. Population: A total of 16 healthy subjects (56 ± 6 years, 0 male) and 11 dialysis patients (60.3 ± 12.3 years, 9 male; dialysis time per week 15 ± 3.5 hours, dialysis duration 31.4 ± 27.9 months). Field Strength/Sequence: A 3 T; 3D spoiled gradient echo. Assessment: LWSrel, a measurement of the water... (More)
Background: Optimal fluid status is an important issue in hemodialysis. Clinical evaluation of volume status and different diagnostic tools are used to determine hydration status in these patients. However, there is still no accurate method for this assessment. Purpose: To propose and evaluate relative lean water signal (LWSrel) as a water–fat MRI-based tissue hydration measurement. Study Type: Prospective. Population: A total of 16 healthy subjects (56 ± 6 years, 0 male) and 11 dialysis patients (60.3 ± 12.3 years, 9 male; dialysis time per week 15 ± 3.5 hours, dialysis duration 31.4 ± 27.9 months). Field Strength/Sequence: A 3 T; 3D spoiled gradient echo. Assessment: LWSrel, a measurement of the water concentration of tissue, was estimated from fat-referenced MR images. Segmentations of total adipose tissue as well as thigh and calf muscles were used to measure LWSrel and tissue volumes. LWSrel was compared between healthy subjects and dialysis patients, the latter before and after dialysis. Bioimpedance-based body composition monitor over hydration (BCM OH) was also measured. Statistical Tests: T-tests were used to compare differences between the healthy subjects and dialysis patients, as well as changes between before and after dialysis. Pearson correlation was calculated between MRI and non-MRI biomarkers. A P value <0.05 was considered statistically significant. Results: The LWSrel in adipose tissue was significantly higher in the dialysis cohort compared with the healthy cohort (246.8% ± 60.0% vs. 100.0% ± 10.8%) and decreased significantly after dialysis (246.8 ± 60.0% vs. 233.8 ± 63.4%). Thigh and calf muscle volumes also significantly decreased by 3.78% ± 1.73% and 2.02% ± 2.50% after dialysis. There was a significant correlation between changes in adipose tissue LWSrel and ultrafiltration volume (r = 87), as well as with BCM OH (r = 0.66). Data Conclusion: MRI-based LWSrel and tissue volume measurements are sensitive to tissue hydration changes occurring during dialysis. Evidence Level: 2. Technical Efficacy: Stage 3.
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- author
- Karlsson, Markus ; Indurain, Ainhoa ; Romu, Thobias ; Tunon, Patrik ; Segelmark, Mårten LU ; Uhlin, Fredrik LU ; Fernström, Anders and Leinhard, Olof Dahlqvist
- organization
- publishing date
- 2023-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chemical shift imaging, dialysis, fat-water imaging, over hydration
- in
- Journal of Magnetic Resonance Imaging
- volume
- 58
- issue
- 2
- pages
- 9 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:36591977
- scopus:85144663710
- ISSN
- 1053-1807
- DOI
- 10.1002/jmri.28581
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2023 International Society for Magnetic Resonance in Medicine.
- id
- 84306ffb-bf7a-420d-bc7c-af73a435067d
- date added to LUP
- 2024-01-12 10:59:34
- date last changed
- 2024-04-27 06:23:04
@article{84306ffb-bf7a-420d-bc7c-af73a435067d,
abstract = {{<p>Background: Optimal fluid status is an important issue in hemodialysis. Clinical evaluation of volume status and different diagnostic tools are used to determine hydration status in these patients. However, there is still no accurate method for this assessment. Purpose: To propose and evaluate relative lean water signal (LWS<sub>rel</sub>) as a water–fat MRI-based tissue hydration measurement. Study Type: Prospective. Population: A total of 16 healthy subjects (56 ± 6 years, 0 male) and 11 dialysis patients (60.3 ± 12.3 years, 9 male; dialysis time per week 15 ± 3.5 hours, dialysis duration 31.4 ± 27.9 months). Field Strength/Sequence: A 3 T; 3D spoiled gradient echo. Assessment: LWS<sub>rel</sub>, a measurement of the water concentration of tissue, was estimated from fat-referenced MR images. Segmentations of total adipose tissue as well as thigh and calf muscles were used to measure LWS<sub>rel</sub> and tissue volumes. LWS<sub>rel</sub> was compared between healthy subjects and dialysis patients, the latter before and after dialysis. Bioimpedance-based body composition monitor over hydration (BCM OH) was also measured. Statistical Tests: T-tests were used to compare differences between the healthy subjects and dialysis patients, as well as changes between before and after dialysis. Pearson correlation was calculated between MRI and non-MRI biomarkers. A P value <0.05 was considered statistically significant. Results: The LWS<sub>rel</sub> in adipose tissue was significantly higher in the dialysis cohort compared with the healthy cohort (246.8% ± 60.0% vs. 100.0% ± 10.8%) and decreased significantly after dialysis (246.8 ± 60.0% vs. 233.8 ± 63.4%). Thigh and calf muscle volumes also significantly decreased by 3.78% ± 1.73% and 2.02% ± 2.50% after dialysis. There was a significant correlation between changes in adipose tissue LWS<sub>rel</sub> and ultrafiltration volume (r = 87), as well as with BCM OH (r = 0.66). Data Conclusion: MRI-based LWS<sub>rel</sub> and tissue volume measurements are sensitive to tissue hydration changes occurring during dialysis. Evidence Level: 2. Technical Efficacy: Stage 3.</p>}},
author = {{Karlsson, Markus and Indurain, Ainhoa and Romu, Thobias and Tunon, Patrik and Segelmark, Mårten and Uhlin, Fredrik and Fernström, Anders and Leinhard, Olof Dahlqvist}},
issn = {{1053-1807}},
keywords = {{chemical shift imaging; dialysis; fat-water imaging; over hydration}},
language = {{eng}},
number = {{2}},
pages = {{652--660}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Magnetic Resonance Imaging}},
title = {{Assessing Tissue Hydration Dynamics Based on Water/Fat Separated MRI}},
url = {{http://dx.doi.org/10.1002/jmri.28581}},
doi = {{10.1002/jmri.28581}},
volume = {{58}},
year = {{2023}},
}