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Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome

Karpman, Diana LU and Tati, Ramesh LU (2016) In Kidney International 90(4). p.9-726
Abstract

Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Kidney International
volume
90
issue
4
pages
4 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85015392794
ISSN
1523-1755
DOI
10.1016/j.kint.2016.07.002
language
English
LU publication?
yes
id
846062da-7d99-4f2c-93e5-2ef07fea7bd0
date added to LUP
2017-02-08 15:47:44
date last changed
2017-06-11 05:13:18
@misc{846062da-7d99-4f2c-93e5-2ef07fea7bd0,
  abstract     = {<p>Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.</p>},
  author       = {Karpman, Diana and Tati, Ramesh},
  issn         = {1523-1755},
  keyword      = {Journal Article},
  language     = {eng},
  number       = {4},
  pages        = {9--726},
  publisher    = {Nature Publishing Group},
  series       = {Kidney International},
  title        = {Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome},
  url          = {http://dx.doi.org/10.1016/j.kint.2016.07.002},
  volume       = {90},
  year         = {2016},
}