Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome
Karpman, Diana LU
and Tati, Ramesh
LU
(2016)
In Kidney International
90(4).
p.9-726
- Abstract
Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/846062da-7d99-4f2c-93e5-2ef07fea7bd0
- author
- Karpman, Diana
LU
and Tati, Ramesh
LU
- organization
- publishing date
- 2016-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Journal Article
- in
- Kidney International
- volume
- 90
- issue
- 4
- pages
- 4 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:27633864
- scopus:85015392794
- wos:000384388800004
- ISSN
- 1523-1755
- DOI
- 10.1016/j.kint.2016.07.002
- language
- English
- LU publication?
- yes
- id
- 846062da-7d99-4f2c-93e5-2ef07fea7bd0
- date added to LUP
- 2017-02-08 15:47:44
- date last changed
- 2025-10-14 13:29:43
@misc{846062da-7d99-4f2c-93e5-2ef07fea7bd0,
abstract = {{<p>Complement is activated during Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS). There is evidence of complement activation via the alternative pathway in STEC-HUS patients as well as from in vivo and in vitro models. Ozaki et al. demonstrate activation of the mannose-binding lectin (MBL) pathway in Shiga toxin-treated mice expressing human MBL2, but lacking murine Mbls. Treatment with anti-human MBL2 antibody was protective, suggesting that MBL pathway activation also contributes to Shiga toxin-mediated renal injury.</p>}},
author = {{Karpman, Diana and Tati, Ramesh}},
issn = {{1523-1755}},
keywords = {{Journal Article}},
language = {{eng}},
number = {{4}},
pages = {{9--726}},
publisher = {{Nature Publishing Group}},
series = {{Kidney International}},
title = {{Complement contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome}},
url = {{http://dx.doi.org/10.1016/j.kint.2016.07.002}},
doi = {{10.1016/j.kint.2016.07.002}},
volume = {{90}},
year = {{2016}},
}