In vitro effects of a thromboxane A2-analogue U-46619 and noradrenaline on contractions of the human thoracic duct
(1991) In Lymphology 24(3). p.113-115- Abstract
- A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic and phasic contractions. At a noradrenaline concentration of 10(-5)M the phasic contractions had a frequency of 5 min-1. The highest frequency, 9 min-1, was recorded with 3 x 10(-10)M of U-46619 present in the bath. Noradrenaline had a mean Emax of 50% of the previous K+ (124mM)-induced contraction, and the mean pEC50-value was 6.7. The Emax and... (More)
- A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic and phasic contractions. At a noradrenaline concentration of 10(-5)M the phasic contractions had a frequency of 5 min-1. The highest frequency, 9 min-1, was recorded with 3 x 10(-10)M of U-46619 present in the bath. Noradrenaline had a mean Emax of 50% of the previous K+ (124mM)-induced contraction, and the mean pEC50-value was 6.7. The Emax and pEC50-values of U-46619 were 142% and 9.5, respectively. Postjunctional alpha-adrenoceptors and thromboxane A2-receptors may play a role in the contractility of the human thoracic duct. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106078
- author
- Sjöberg, Trygve LU and Steen, Stig LU
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Lymphology
- volume
- 24
- issue
- 3
- pages
- 113 - 115
- publisher
- International Society of Lymphology
- external identifiers
-
- pmid:1753802
- scopus:0026072252
- ISSN
- 0024-7766
- language
- English
- LU publication?
- yes
- id
- 84689388-80c9-4e35-8321-6e6a9c6a95ef (old id 1106078)
- date added to LUP
- 2016-04-01 15:56:18
- date last changed
- 2021-01-03 04:18:00
@article{84689388-80c9-4e35-8321-6e6a9c6a95ef,
abstract = {{A piece of a human thoracic duct removed at operation was investigated in organ baths. The duct was cut in 8 ring segments each about 1mm long and isometric tension recorded. The segments were exposed to a potassium rich (124mM) Krebs buffer solution. In only two of the segments were contractions induced (7.2 and 1.0mN, respectively). Noradrenaline and the thromboxane mimetic U-46619 induced tonic and phasic contractions. At a noradrenaline concentration of 10(-5)M the phasic contractions had a frequency of 5 min-1. The highest frequency, 9 min-1, was recorded with 3 x 10(-10)M of U-46619 present in the bath. Noradrenaline had a mean Emax of 50% of the previous K+ (124mM)-induced contraction, and the mean pEC50-value was 6.7. The Emax and pEC50-values of U-46619 were 142% and 9.5, respectively. Postjunctional alpha-adrenoceptors and thromboxane A2-receptors may play a role in the contractility of the human thoracic duct.}},
author = {{Sjöberg, Trygve and Steen, Stig}},
issn = {{0024-7766}},
language = {{eng}},
number = {{3}},
pages = {{113--115}},
publisher = {{International Society of Lymphology}},
series = {{Lymphology}},
title = {{In vitro effects of a thromboxane A2-analogue U-46619 and noradrenaline on contractions of the human thoracic duct}},
volume = {{24}},
year = {{1991}},
}