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Is the incidence of recurrent pregnancy loss increasing? A retrospective register-based study in Sweden

Rasmark Roepke, Emma; Matthiesen, Leif LU ; Rylance, Rebecca LU and Christiansen, Ole Bjarne (2017) In Acta Obstetricia et Gynecologica Scandinavica 96(11). p.1365-1372
Abstract

Introduction: The aim of this study was to estimate the incidence of recurrent pregnancy loss (RPL). The prevalence of RPL defined as three or more consecutive miscarriages before gestation week 22, is often stated to be 1%. To our knowledge no study has estimated the incidence of RPL, which might be more informative and clinically relevant than the prevalence. Material and methods: This retrospective register-based study was conducted from 2003 until 2012 in Sweden with data provided by the Swedish National Board of Health and Welfare. In all, 6852 women were registered with the diagnoses of RPL in the National Patient Register. The incidence of RPL is the number of new women receiving the RPL diagnosis per year in the numerator and... (More)

Introduction: The aim of this study was to estimate the incidence of recurrent pregnancy loss (RPL). The prevalence of RPL defined as three or more consecutive miscarriages before gestation week 22, is often stated to be 1%. To our knowledge no study has estimated the incidence of RPL, which might be more informative and clinically relevant than the prevalence. Material and methods: This retrospective register-based study was conducted from 2003 until 2012 in Sweden with data provided by the Swedish National Board of Health and Welfare. In all, 6852 women were registered with the diagnoses of RPL in the National Patient Register. The incidence of RPL is the number of new women receiving the RPL diagnosis per year in the numerator and population at risk in the denominator. Results: For each year, from 2003 to 2012, the incidence was calculated in two different risk populations: [1] all women aged 18–42 years, and [2] all women registered as being pregnant (deliveries or miscarriages). The average incidence in the study period was 53 per 100 000 (0.05%) in women aged 18–42 years and 650 per 100 000 (0.65%) in women who had achieved pregnancy in the period. The incidence of RPL in the two risk populations increased by 74 and 58%, respectively, during the study period. Conclusion: This study suggests that the incidence of RPL increased during the 10-year period studied. Causes can only be speculated upon in this study design, but might be associated with environmental changes, as the increase was fairly rapid.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
abortion (habitual), epidemiology, incidence, Recurrent pregnancy loss
in
Acta Obstetricia et Gynecologica Scandinavica
volume
96
issue
11
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85031494495
ISSN
0001-6349
DOI
10.1111/aogs.13210
language
English
LU publication?
yes
id
84e43615-e914-4aa7-9ae5-a1ef19d63cc3
date added to LUP
2017-11-12 16:05:06
date last changed
2018-01-07 12:25:34
@article{84e43615-e914-4aa7-9ae5-a1ef19d63cc3,
  abstract     = {<p>Introduction: The aim of this study was to estimate the incidence of recurrent pregnancy loss (RPL). The prevalence of RPL defined as three or more consecutive miscarriages before gestation week 22, is often stated to be 1%. To our knowledge no study has estimated the incidence of RPL, which might be more informative and clinically relevant than the prevalence. Material and methods: This retrospective register-based study was conducted from 2003 until 2012 in Sweden with data provided by the Swedish National Board of Health and Welfare. In all, 6852 women were registered with the diagnoses of RPL in the National Patient Register. The incidence of RPL is the number of new women receiving the RPL diagnosis per year in the numerator and population at risk in the denominator. Results: For each year, from 2003 to 2012, the incidence was calculated in two different risk populations: [1] all women aged 18–42 years, and [2] all women registered as being pregnant (deliveries or miscarriages). The average incidence in the study period was 53 per 100 000 (0.05%) in women aged 18–42 years and 650 per 100 000 (0.65%) in women who had achieved pregnancy in the period. The incidence of RPL in the two risk populations increased by 74 and 58%, respectively, during the study period. Conclusion: This study suggests that the incidence of RPL increased during the 10-year period studied. Causes can only be speculated upon in this study design, but might be associated with environmental changes, as the increase was fairly rapid.</p>},
  author       = {Rasmark Roepke, Emma and Matthiesen, Leif and Rylance, Rebecca and Christiansen, Ole Bjarne},
  issn         = {0001-6349},
  keyword      = {abortion (habitual),epidemiology,incidence,Recurrent pregnancy loss},
  language     = {eng},
  month        = {11},
  number       = {11},
  pages        = {1365--1372},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Is the incidence of recurrent pregnancy loss increasing? A retrospective register-based study in Sweden},
  url          = {http://dx.doi.org/10.1111/aogs.13210},
  volume       = {96},
  year         = {2017},
}