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High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women

Sveen, Kari Anne LU ; Smith, Gustav LU ; Björkbacka, Harry LU orcid ; Orho-Melander, Marju LU ; Engström, Gunnar LU ; Gonçalves, Isabel LU orcid ; Melander, Olle LU orcid ; Nilsson, Jan LU and Bengtsson, Eva LU orcid (2022) In Journal of Internal Medicine 291(2). p.207-217
Abstract

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. However, whether these autoantibodies are associated with occurrence of AF is not known. We investigated autoantibodies against oxidized apolipoprotein B100 peptides and incidence of AF in a large population-based cohort.

METHODS: IgM and IgG against native and aldehyde-modified apoB100 peptides 210 (p210) and 45 were analyzed by enzyme-linked... (More)

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. However, whether these autoantibodies are associated with occurrence of AF is not known. We investigated autoantibodies against oxidized apolipoprotein B100 peptides and incidence of AF in a large population-based cohort.

METHODS: IgM and IgG against native and aldehyde-modified apoB100 peptides 210 (p210) and 45 were analyzed by enzyme-linked immunosorbent assay (ELISA) in 5169 individuals from the Malmö Diet and Cancer cohort.

RESULTS: Seven hundred sixty-nine incident AF cases were recorded during a follow-up of 21.3 years. Individuals with high levels of IgM against native p210 at baseline had a lower risk to develop AF; however, the association did not remain after adjustment for age and sex. Women had higher levels of IgM against native p210 than men (0.70 ± 0.22 AU vs. 0.63 ± 0.21 AU, p < 0.001). The association of IgM against native p210 and AF was significantly different between sexes (p for interaction = 0.024), where females with high IgM against p210 had a lower risk for incidence of AF (hazard ratio [95% confidence interval] 4th versus 1st quartile: 0.67 [0.49-0.91]; p = 0.01) after adjusting for risk factors and comorbidities.

CONCLUSION: These findings support an association of humoral autoimmunity with AF.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
291
issue
2
pages
207 - 217
publisher
Wiley-Blackwell
external identifiers
  • scopus:85115659671
  • pmid:34532909
ISSN
1365-2796
DOI
10.1111/joim.13393
language
English
LU publication?
yes
additional info
© 2021 The Association for the Publication of the Journal of Internal Medicine.
id
84f58205-9edf-4275-b782-657f328117c6
date added to LUP
2021-10-13 10:52:26
date last changed
2024-06-15 18:07:33
@article{84f58205-9edf-4275-b782-657f328117c6,
  abstract     = {{<p>BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. However, whether these autoantibodies are associated with occurrence of AF is not known. We investigated autoantibodies against oxidized apolipoprotein B100 peptides and incidence of AF in a large population-based cohort.</p><p>METHODS: IgM and IgG against native and aldehyde-modified apoB100 peptides 210 (p210) and 45 were analyzed by enzyme-linked immunosorbent assay (ELISA) in 5169 individuals from the Malmö Diet and Cancer cohort.</p><p>RESULTS: Seven hundred sixty-nine incident AF cases were recorded during a follow-up of 21.3 years. Individuals with high levels of IgM against native p210 at baseline had a lower risk to develop AF; however, the association did not remain after adjustment for age and sex. Women had higher levels of IgM against native p210 than men (0.70 ± 0.22 AU vs. 0.63 ± 0.21 AU, p &lt; 0.001). The association of IgM against native p210 and AF was significantly different between sexes (p for interaction = 0.024), where females with high IgM against p210 had a lower risk for incidence of AF (hazard ratio [95% confidence interval] 4th versus 1st quartile: 0.67 [0.49-0.91]; p = 0.01) after adjusting for risk factors and comorbidities.</p><p>CONCLUSION: These findings support an association of humoral autoimmunity with AF.</p>}},
  author       = {{Sveen, Kari Anne and Smith, Gustav and Björkbacka, Harry and Orho-Melander, Marju and Engström, Gunnar and Gonçalves, Isabel and Melander, Olle and Nilsson, Jan and Bengtsson, Eva}},
  issn         = {{1365-2796}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{207--217}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Internal Medicine}},
  title        = {{High levels of autoantibodies against apoB100 p210 are associated with lower incidence of atrial fibrillation in women}},
  url          = {{http://dx.doi.org/10.1111/joim.13393}},
  doi          = {{10.1111/joim.13393}},
  volume       = {{291}},
  year         = {{2022}},
}