Advanced

Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells.

Meißner, Tobias; Seckinger, Anja; Hemminki, Kari LU ; Bertsch, Uta; Försti, Asta LU ; Haenel, Mathias; Duering, Jan; Salwender, Hans; Goldschmidt, Hartmut and Morgan, Gareth J, et al. (2015) In BMC Medical Genomics 8(1).
Abstract
Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability to immediately freeze bone marrow aspirates or use RNA stabilization reagents. As a result in multi-center MM trials sample processing delay due to shipping may be an important confounder of molecular analyses and risk stratification based on GEP data.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Medical Genomics
volume
8
issue
1
publisher
BioMed Central
external identifiers
  • pmid:26714877
  • wos:000367322100001
  • scopus:84951950391
ISSN
1755-8794
DOI
10.1186/s12920-015-0161-6
language
English
LU publication?
yes
id
e7061a7f-b580-4cdf-8132-ad7261cfcd48 (old id 8500226)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26714877?dopt=Abstract
date added to LUP
2016-01-06 20:52:39
date last changed
2017-07-30 04:00:25
@article{e7061a7f-b580-4cdf-8132-ad7261cfcd48,
  abstract     = {Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability to immediately freeze bone marrow aspirates or use RNA stabilization reagents. As a result in multi-center MM trials sample processing delay due to shipping may be an important confounder of molecular analyses and risk stratification based on GEP data.},
  articleno    = {85},
  author       = {Meißner, Tobias and Seckinger, Anja and Hemminki, Kari and Bertsch, Uta and Försti, Asta and Haenel, Mathias and Duering, Jan and Salwender, Hans and Goldschmidt, Hartmut and Morgan, Gareth J and Hose, Dirk and Weinhold, Niels},
  issn         = {1755-8794},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Medical Genomics},
  title        = {Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells.},
  url          = {http://dx.doi.org/10.1186/s12920-015-0161-6},
  volume       = {8},
  year         = {2015},
}