Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells.
(2015) In BMC Medical Genomics 8(1).- Abstract
- Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability to immediately freeze bone marrow aspirates or use RNA stabilization reagents. As a result in multi-center MM trials sample processing delay due to shipping may be an important confounder of molecular analyses and risk stratification based on GEP data.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8500226
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Medical Genomics
- volume
- 8
- issue
- 1
- article number
- 85
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:26714877
- wos:000367322100001
- scopus:84951950391
- pmid:26714877
- ISSN
- 1755-8794
- DOI
- 10.1186/s12920-015-0161-6
- language
- English
- LU publication?
- yes
- id
- e7061a7f-b580-4cdf-8132-ad7261cfcd48 (old id 8500226)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26714877?dopt=Abstract
- date added to LUP
- 2016-04-01 13:15:50
- date last changed
- 2022-03-13 23:02:15
@article{e7061a7f-b580-4cdf-8132-ad7261cfcd48, abstract = {{Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability to immediately freeze bone marrow aspirates or use RNA stabilization reagents. As a result in multi-center MM trials sample processing delay due to shipping may be an important confounder of molecular analyses and risk stratification based on GEP data.}}, author = {{Meißner, Tobias and Seckinger, Anja and Hemminki, Kari and Bertsch, Uta and Försti, Asta and Haenel, Mathias and Duering, Jan and Salwender, Hans and Goldschmidt, Hartmut and Morgan, Gareth J and Hose, Dirk and Weinhold, Niels}}, issn = {{1755-8794}}, language = {{eng}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{BMC Medical Genomics}}, title = {{Profound impact of sample processing delay on gene expression of multiple myeloma plasma cells.}}, url = {{http://dx.doi.org/10.1186/s12920-015-0161-6}}, doi = {{10.1186/s12920-015-0161-6}}, volume = {{8}}, year = {{2015}}, }