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A novel approach to measure local cerebral haematocrit using MRI.

Calamante, Fernando; Ahlgren, André LU ; van Osch, Matthias Jp and Knutsson, Linda LU (2016) In Journal of Cerebral Blood Flow and Metabolism 36(4). p.768-780
Abstract
The percentage blood volume occupied by red blood cells is known as haematocrit. While it is straightforward to measure haematocrit in large arteries, it is very challenging to do it in microvasculature (cerebral haematocrit). Currently, this can only be done using invasive methods (e.g. PET), but their use is very limited. Local variations in cerebral haematocrit have been reported in various brain abnormalities (e.g. stroke, tumours). We propose a new approach to image cerebral haematocrit using MRI, which relies on combining data from two measurements: one that provides haematocrit-weighted and other one haematocrit-independent values of the same parameter, thus providing an easily obtainable measurement of this important physiological... (More)
The percentage blood volume occupied by red blood cells is known as haematocrit. While it is straightforward to measure haematocrit in large arteries, it is very challenging to do it in microvasculature (cerebral haematocrit). Currently, this can only be done using invasive methods (e.g. PET), but their use is very limited. Local variations in cerebral haematocrit have been reported in various brain abnormalities (e.g. stroke, tumours). We propose a new approach to image cerebral haematocrit using MRI, which relies on combining data from two measurements: one that provides haematocrit-weighted and other one haematocrit-independent values of the same parameter, thus providing an easily obtainable measurement of this important physiological parameter. Four different implementations are described, with one illustrated as proof-of-concept using data from healthy subjects. Cerebral haematocrit measurements were found to be in general agreement with literature values from invasive techniques (e.g. cerebral/arterial ratios of 0.88 and 0.86 for sub-cortical and cortical regions), and showed good test-retest reproducibility (e.g. coefficient-of-variation: 15% and 13% for those regions). The method was also able to detect statistically significant haematocrit gender differences in cortical regions (p < 0.01). The proposed MRI technique should have important applications in various neurological diseases, such as in stroke and brain tumours. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cerebral Blood Flow and Metabolism
volume
36
issue
4
pages
768 - 780
publisher
Nature Publishing Group
external identifiers
  • PMID:26661152
  • WOS:000373355900011
  • Scopus:84962439842
ISSN
1559-7016
DOI
10.1177/0271678X15606143
language
English
LU publication?
yes
id
cb6f06f8-e87d-43c7-b3ec-6f5d4247d184 (old id 8505041)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26661152?dopt=Abstract
date added to LUP
2016-01-05 18:15:17
date last changed
2017-01-08 05:34:08
@article{cb6f06f8-e87d-43c7-b3ec-6f5d4247d184,
  abstract     = {The percentage blood volume occupied by red blood cells is known as haematocrit. While it is straightforward to measure haematocrit in large arteries, it is very challenging to do it in microvasculature (cerebral haematocrit). Currently, this can only be done using invasive methods (e.g. PET), but their use is very limited. Local variations in cerebral haematocrit have been reported in various brain abnormalities (e.g. stroke, tumours). We propose a new approach to image cerebral haematocrit using MRI, which relies on combining data from two measurements: one that provides haematocrit-weighted and other one haematocrit-independent values of the same parameter, thus providing an easily obtainable measurement of this important physiological parameter. Four different implementations are described, with one illustrated as proof-of-concept using data from healthy subjects. Cerebral haematocrit measurements were found to be in general agreement with literature values from invasive techniques (e.g. cerebral/arterial ratios of 0.88 and 0.86 for sub-cortical and cortical regions), and showed good test-retest reproducibility (e.g. coefficient-of-variation: 15% and 13% for those regions). The method was also able to detect statistically significant haematocrit gender differences in cortical regions (p &lt; 0.01). The proposed MRI technique should have important applications in various neurological diseases, such as in stroke and brain tumours.},
  author       = {Calamante, Fernando and Ahlgren, André and van Osch, Matthias Jp and Knutsson, Linda},
  issn         = {1559-7016},
  language     = {eng},
  number       = {4},
  pages        = {768--780},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {A novel approach to measure local cerebral haematocrit using MRI.},
  url          = {http://dx.doi.org/10.1177/0271678X15606143},
  volume       = {36},
  year         = {2016},
}