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Non-coding RNAs in Prostate Cancer: From Discovery to Clinical Applications.

Ceder, Yvonne LU (2016) In Advances in Experimental Medicine and Biology 886. p.155-170
Abstract
Prostate cancer is a heterogeneous disease for which the molecular mechanisms are still not fully elucidated. Prostate cancer research has traditionally focused on genomic and epigenetic alterations affecting the proteome, but over the last decade non-coding RNAs, especially microRNAs, have been recognized to play a key role in prostate cancer progression. A considerable number of individual microRNAs have been found to be deregulated in prostate cancer and their biological significance elucidated in functional studies. This review will delineate the current advances regarding the involvement of microRNAs and their targets in prostate cancer biology as well as their potential usage in the clinical management of the disease. The main focus... (More)
Prostate cancer is a heterogeneous disease for which the molecular mechanisms are still not fully elucidated. Prostate cancer research has traditionally focused on genomic and epigenetic alterations affecting the proteome, but over the last decade non-coding RNAs, especially microRNAs, have been recognized to play a key role in prostate cancer progression. A considerable number of individual microRNAs have been found to be deregulated in prostate cancer and their biological significance elucidated in functional studies. This review will delineate the current advances regarding the involvement of microRNAs and their targets in prostate cancer biology as well as their potential usage in the clinical management of the disease. The main focus will be on microRNAs contributing to initiation and progression of prostate cancer, including androgen signalling, cellular plasticity, stem cells biology and metastatic processes. To conclude, implications on potential future microRNA-based therapeutics based on the recent advances regarding the interplay between microRNAs and their targets are discussed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Advances in Experimental Medicine and Biology
editor
Wilhelm, Dagmar; Bernard, Pascal; and
volume
886
pages
155 - 170
external identifiers
  • pmid:26659491
  • scopus:84949780674
  • wos:000370340700009
ISSN
0065-2598
ISBN
978-94-017-7415-4
978-94-017-7417-8
DOI
10.1007/978-94-017-7417-8_8
language
English
LU publication?
yes
id
f36a90c8-615b-4355-9b3e-6e8381878184 (old id 8505110)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26659491?dopt=Abstract
date added to LUP
2016-01-12 12:24:43
date last changed
2017-07-30 05:11:57
@inbook{f36a90c8-615b-4355-9b3e-6e8381878184,
  abstract     = {Prostate cancer is a heterogeneous disease for which the molecular mechanisms are still not fully elucidated. Prostate cancer research has traditionally focused on genomic and epigenetic alterations affecting the proteome, but over the last decade non-coding RNAs, especially microRNAs, have been recognized to play a key role in prostate cancer progression. A considerable number of individual microRNAs have been found to be deregulated in prostate cancer and their biological significance elucidated in functional studies. This review will delineate the current advances regarding the involvement of microRNAs and their targets in prostate cancer biology as well as their potential usage in the clinical management of the disease. The main focus will be on microRNAs contributing to initiation and progression of prostate cancer, including androgen signalling, cellular plasticity, stem cells biology and metastatic processes. To conclude, implications on potential future microRNA-based therapeutics based on the recent advances regarding the interplay between microRNAs and their targets are discussed.},
  author       = {Ceder, Yvonne},
  editor       = {Wilhelm, Dagmar and Bernard, Pascal},
  isbn         = {978-94-017-7415-4},
  issn         = {0065-2598},
  language     = {eng},
  pages        = {155--170},
  series       = {Advances in Experimental Medicine and Biology},
  title        = {Non-coding RNAs in Prostate Cancer: From Discovery to Clinical Applications.},
  url          = {http://dx.doi.org/10.1007/978-94-017-7417-8_8},
  volume       = {886},
  year         = {2016},
}