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A novel mutation on the transferrin gene abolishes one N-glycosylation site and alters the pattern of transferrin isoforms, mimicking that observed after excessive alcohol consumption.

Grahn, Ammi; Bengtson, Per LU ; Eklund, Erik and Asin-Cayuela, Jorge (2016) In Clinical Biochemistry 49(6). p.511-513
Abstract
In the process of obtaining a driver's license, a healthy 28year old man presented increased levels of disialo-transferrin (TF) (approx. 20%, ref. value<2) by HPLC analysis of TF isoforms (%CDT), while other markers of excessive alcohol consumption (PEth, MCV and γ-GT) were in the normal range. The objective of this study was to determine the cause of the increased %CDT levels.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
49
issue
6
pages
511 - 513
publisher
Elsevier
external identifiers
  • pmid:26656560
  • scopus:84951088635
  • wos:000373209700018
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2015.12.001
language
English
LU publication?
yes
id
d77e3881-9546-4419-9fb5-69ae32706542 (old id 8505155)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26656560?dopt=Abstract
date added to LUP
2016-01-05 17:34:56
date last changed
2017-05-28 04:33:25
@article{d77e3881-9546-4419-9fb5-69ae32706542,
  abstract     = {In the process of obtaining a driver's license, a healthy 28year old man presented increased levels of disialo-transferrin (TF) (approx. 20%, ref. value&lt;2) by HPLC analysis of TF isoforms (%CDT), while other markers of excessive alcohol consumption (PEth, MCV and γ-GT) were in the normal range. The objective of this study was to determine the cause of the increased %CDT levels.},
  author       = {Grahn, Ammi and Bengtson, Per and Eklund, Erik and Asin-Cayuela, Jorge},
  issn         = {1873-2933},
  language     = {eng},
  number       = {6},
  pages        = {511--513},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {A novel mutation on the transferrin gene abolishes one N-glycosylation site and alters the pattern of transferrin isoforms, mimicking that observed after excessive alcohol consumption.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2015.12.001},
  volume       = {49},
  year         = {2016},
}