Advanced

Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson's Disease.

Fauser, Mareike; Löhle, Matthias; Ebersbach, Georg; Odin, Per LU ; Fuchs, Gerd; Jost, Wolfgang H; Chaudhuri, K Ray; Koch, Rainer and Storch, Alexander (2015) In Journal of Parkinson's Disease 5(4). p.737-741
Abstract
Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient variability in frequency and severity of NMS during a series of five patient-perceived motor On and Off periods in 38 fluctuating PD patients from the multicenter NonMotorFluctuations in PD study using a visual analogue scale. NMS frequency and severity appeared moderately variable in both motor states within individual patients. Symptom severity ranges between motor states showed high variability and were larger in motor Off states for most NMS.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Parkinson's Disease
volume
5
issue
4
pages
737 - 741
publisher
IOS Press
external identifiers
  • pmid:26639660
  • wos:000367308200006
  • scopus:84952645923
ISSN
1877-718X
DOI
10.3233/JPD-150656
language
English
LU publication?
yes
id
22ee8e21-422d-4e4f-9422-97640a677da3 (old id 8505603)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26639660?dopt=Abstract
date added to LUP
2016-01-04 22:10:33
date last changed
2017-10-22 03:15:55
@article{22ee8e21-422d-4e4f-9422-97640a677da3,
  abstract     = {Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient variability in frequency and severity of NMS during a series of five patient-perceived motor On and Off periods in 38 fluctuating PD patients from the multicenter NonMotorFluctuations in PD study using a visual analogue scale. NMS frequency and severity appeared moderately variable in both motor states within individual patients. Symptom severity ranges between motor states showed high variability and were larger in motor Off states for most NMS.},
  author       = {Fauser, Mareike and Löhle, Matthias and Ebersbach, Georg and Odin, Per and Fuchs, Gerd and Jost, Wolfgang H and Chaudhuri, K Ray and Koch, Rainer and Storch, Alexander},
  issn         = {1877-718X},
  language     = {eng},
  number       = {4},
  pages        = {737--741},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson's Disease.},
  url          = {http://dx.doi.org/10.3233/JPD-150656},
  volume       = {5},
  year         = {2015},
}