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Survival in familial and non-familial breast cancer by age and stage at diagnosis.

Kharazmi, Elham; Försti, Asta LU ; Sundquist, Kristina LU and Hemminki, Kari LU (2016) In European Journal of Cancer 52. p.10-18
Abstract
We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR:... (More)
We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0-3.7) or multiple (HR: 2.4-7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (>40). Young familial BC patients (age <40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer
volume
52
pages
10 - 18
publisher
IFAC & Elsevier Ltd.
external identifiers
  • pmid:26630529
  • wos:000367031000001
  • scopus:84948406634
ISSN
1879-0852
DOI
10.1016/j.ejca.2015.09.015
language
English
LU publication?
yes
id
46183124-4406-4cbf-95d0-a9bc8180c00a (old id 8505749)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26630529?dopt=Abstract
date added to LUP
2016-01-12 12:15:19
date last changed
2017-07-09 03:21:48
@article{46183124-4406-4cbf-95d0-a9bc8180c00a,
  abstract     = {We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling &gt;14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (&gt;40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age &lt;40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0-3.7) or multiple (HR: 2.4-7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (&gt;40). Young familial BC patients (age &lt;40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC.},
  author       = {Kharazmi, Elham and Försti, Asta and Sundquist, Kristina and Hemminki, Kari},
  issn         = {1879-0852},
  language     = {eng},
  pages        = {10--18},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Survival in familial and non-familial breast cancer by age and stage at diagnosis.},
  url          = {http://dx.doi.org/10.1016/j.ejca.2015.09.015},
  volume       = {52},
  year         = {2016},
}