Survival in familial and non-familial breast cancer by age and stage at diagnosis.
(2016) In European Journal of Cancer 52. p.10-18- Abstract
- We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR:... (More)
- We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0-3.7) or multiple (HR: 2.4-7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (>40). Young familial BC patients (age <40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8505749
- author
- Kharazmi, Elham ; Försti, Asta LU ; Sundquist, Kristina LU and Hemminki, Kari LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Cancer
- volume
- 52
- pages
- 10 - 18
- publisher
- Elsevier
- external identifiers
-
- pmid:26630529
- wos:000367031000001
- scopus:84948406634
- pmid:26630529
- ISSN
- 1879-0852
- DOI
- 10.1016/j.ejca.2015.09.015
- language
- English
- LU publication?
- yes
- id
- 46183124-4406-4cbf-95d0-a9bc8180c00a (old id 8505749)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26630529?dopt=Abstract
- date added to LUP
- 2016-04-01 10:54:40
- date last changed
- 2022-04-20 07:21:11
@article{46183124-4406-4cbf-95d0-a9bc8180c00a, abstract = {{We aimed to compare the survival in familial and sporadic breast cancer (BC) patients who were diagnosed at an identical age and TNM stage. The Nationwide Swedish Family-Cancer Database including all Swedes born after 1931 and their biological parents, totalling >14.7 million individuals, was used. Hazard ratios (HRs) were calculated for women with BC in a first-degree relative (FDR) versus BC patients without positive family history. There was no difference in survival of familial BC patients who were diagnosed at higher TNM status or older age (>40) compared to sporadic BC cases diagnosed at the same late TNM stage. Young BC patients (age <40) in early stages had the worst survival when their FDR was diagnosed with single (HR: 2.0-3.7) or multiple (HR: 2.4-7.1) BC at any age. We concluded that there is no difference in survival of familial and non-familial BC patients who are diagnosed at higher TNM status or older ages (>40). Young familial BC patients (age <40), diagnosed at early stage, have the poorer survival compared to sporadic cases. Our results urge the need for identifying the underling genetic component for such a difference in survival of familial BC.}}, author = {{Kharazmi, Elham and Försti, Asta and Sundquist, Kristina and Hemminki, Kari}}, issn = {{1879-0852}}, language = {{eng}}, pages = {{10--18}}, publisher = {{Elsevier}}, series = {{European Journal of Cancer}}, title = {{Survival in familial and non-familial breast cancer by age and stage at diagnosis.}}, url = {{http://dx.doi.org/10.1016/j.ejca.2015.09.015}}, doi = {{10.1016/j.ejca.2015.09.015}}, volume = {{52}}, year = {{2016}}, }