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Drug-eluting balloon (DEB) versus plain old balloon angioplasty (POBA) in the treatment of failing dialysis access : A prospective randomized trial

Fransson, Torbjörn LU orcid ; Gottsäter, Anders LU ; Abdulrasak, Mohammad LU ; Malina, Martin LU and Resch, Timothy LU (2022) In Journal of International Medical Research 50(3).
Abstract

Objective: To compare the efficacy of angioplasty using drug-eluting balloons (DEB) compared with plain old balloon angioplasty (POBA) to reduce the rate of restenosis. Methods: This prospective, single-centre, single-blinded, 1:1 randomized, clinical trial enrolled patients that had primary or restenotic lesions in native upper extremity arteriovenous (AV) fistulas or at the graft-venous anastomosis. Patients were randomized to angioplasty with a POBA or a DEB. The primary effectiveness endpoints were freedom from target lesion revascularization (TLR) and functional status of access circuit at 12 months. Results: A total of 42 (28 male, 14 female; age range, 42–83 years) patients were enrolled. Patients were followed for 12 months. No... (More)

Objective: To compare the efficacy of angioplasty using drug-eluting balloons (DEB) compared with plain old balloon angioplasty (POBA) to reduce the rate of restenosis. Methods: This prospective, single-centre, single-blinded, 1:1 randomized, clinical trial enrolled patients that had primary or restenotic lesions in native upper extremity arteriovenous (AV) fistulas or at the graft-venous anastomosis. Patients were randomized to angioplasty with a POBA or a DEB. The primary effectiveness endpoints were freedom from target lesion revascularization (TLR) and functional status of access circuit at 12 months. Results: A total of 42 (28 male, 14 female; age range, 42–83 years) patients were enrolled. Patients were followed for 12 months. No significant differences were detected between the POBA and DEB groups regarding total number of TLR procedures (31 versus 36, respectively), freedom from TLR (3 versus 4, respectively) and functional status of the access circuit at 12 months (14 of 20 patients [70%] versus 17 of 22 patients [77%], respectively). Conclusion: This clinical trial did not demonstrate any significant differences between DEB angioplasty and standard balloon angioplasty when treating dysfunctional haemodialysis access.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
angioplasty, arteriovenous fistula, Drug-eluting balloon, haemodialysis, paclitaxel, stenosis
in
Journal of International Medical Research
volume
50
issue
3
publisher
SAGE Publications
external identifiers
  • scopus:85127266704
  • pmid:35354342
ISSN
0300-0605
DOI
10.1177/03000605221081662
language
English
LU publication?
yes
id
85185840-e94f-41f5-98f1-b17c5a455f37
date added to LUP
2022-05-09 15:13:18
date last changed
2024-12-22 19:33:59
@article{85185840-e94f-41f5-98f1-b17c5a455f37,
  abstract     = {{<p>Objective: To compare the efficacy of angioplasty using drug-eluting balloons (DEB) compared with plain old balloon angioplasty (POBA) to reduce the rate of restenosis. Methods: This prospective, single-centre, single-blinded, 1:1 randomized, clinical trial enrolled patients that had primary or restenotic lesions in native upper extremity arteriovenous (AV) fistulas or at the graft-venous anastomosis. Patients were randomized to angioplasty with a POBA or a DEB. The primary effectiveness endpoints were freedom from target lesion revascularization (TLR) and functional status of access circuit at 12 months. Results: A total of 42 (28 male, 14 female; age range, 42–83 years) patients were enrolled. Patients were followed for 12 months. No significant differences were detected between the POBA and DEB groups regarding total number of TLR procedures (31 versus 36, respectively), freedom from TLR (3 versus 4, respectively) and functional status of the access circuit at 12 months (14 of 20 patients [70%] versus 17 of 22 patients [77%], respectively). Conclusion: This clinical trial did not demonstrate any significant differences between DEB angioplasty and standard balloon angioplasty when treating dysfunctional haemodialysis access.</p>}},
  author       = {{Fransson, Torbjörn and Gottsäter, Anders and Abdulrasak, Mohammad and Malina, Martin and Resch, Timothy}},
  issn         = {{0300-0605}},
  keywords     = {{angioplasty; arteriovenous fistula; Drug-eluting balloon; haemodialysis; paclitaxel; stenosis}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of International Medical Research}},
  title        = {{Drug-eluting balloon (DEB) versus plain old balloon angioplasty (POBA) in the treatment of failing dialysis access : A prospective randomized trial}},
  url          = {{http://dx.doi.org/10.1177/03000605221081662}},
  doi          = {{10.1177/03000605221081662}},
  volume       = {{50}},
  year         = {{2022}},
}