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Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?

Wiggermann, Vanessa ; Vavasour, Irene M ; Hernandez-Torres, Ernedino ; Helms, Gunther LU ; MacKay, Alex L and Rauscher, Alexander (2019) ISMRM 27th Annual Meeting and Exhibition In Proceedings of the ISMRM 27.
Abstract
The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under different parameter selection. The lowest allowed T2 was found to have the largest effect on correctly estimating the T2 of different water pools as well as the MWF. Lower refocusing FAs led to further underestimation of the MWF.
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Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?
series title
Proceedings of the ISMRM
volume
27
article number
4402
pages
3 pages
publisher
International Society for Magnetic Resonance in Medicine
conference name
ISMRM 27th Annual Meeting and Exhibition
conference location
Montreal, Canada
conference dates
2019-05-11 - 2019-05-16
ISSN
1545-4428
project
T2 mapping and myelin water imaging at 7T using 3D GraSe
language
English
LU publication?
yes
id
852969f9-7ef3-4ab2-b134-543a4e9f30d3
alternative location
http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/4402.html
date added to LUP
2019-05-30 10:46:07
date last changed
2020-08-17 15:07:17
@inproceedings{852969f9-7ef3-4ab2-b134-543a4e9f30d3,
  abstract     = {The ability to determine the myelin water fraction (MWF) in vivo is essential to assessments of neurodevelopmental myelination and myelin damage in neurodegenerative diseases. The analysis of multi-exponential T2 decay data relies on the non-negative-least-squares (NNLS) fitting, which may be sensitive to the chosen fitting parameters. We performed simulations to explore the outcomes of NNLS under different parameter selection. The lowest allowed T2 was found to have the largest effect on correctly estimating the T2 of different water pools as well as the MWF. Lower refocusing FAs led to further underestimation of the MWF.},
  author       = {Wiggermann, Vanessa and Vavasour, Irene M and Hernandez-Torres, Ernedino and Helms, Gunther and MacKay, Alex L and Rauscher, Alexander},
  booktitle    = {Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?},
  issn         = {1545-4428},
  language     = {eng},
  month        = {04},
  publisher    = {International Society for Magnetic Resonance in Medicine},
  series       = {Proceedings of the ISMRM},
  title        = {Non-negative least squares fitting of multi-exponential T2 decay data: Are we able to accurately measure the fraction of myelin water?},
  url          = {https://lup.lub.lu.se/search/ws/files/65200312/Proc.Intl.Soc.Magn.Res.Med.27_2019_4402.pdf},
  volume       = {27},
  year         = {2019},
}