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Low 30-day mortality and low carbapenem-resistance in a decade of Acinetobacter bacteraemia in South Sweden

Ingefors, Erik ; Tverring, Jonas LU orcid ; Nafaa, Fatima ; Jönsson, Niklas ; Karlsson Söbirk, Sara LU orcid ; Kjölvmark, Charlott LU and Ljungquist, Oskar LU (2022) In Infection Ecology and Epidemiology 12(1).
Abstract

Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.

Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.

Results: There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent... (More)

Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.

Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.

Results: There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent risk factors associated with 30-day mortality in the multivariate regression model were Acinetobacter growth in all blood cultures drawn at the day of bacteraemia onset (OR 5.0, 95% CI: 1.8 to 13.7, p= 0.002), baseline functional capacity (1-4 points, OR 2.0, 95% CI: 1.2 to 3.4, p= 0.010) and correct empiric antibiotics at time of culture (OR 3.5 95% CI: 1.0 to 11.8, p= 0.045).

Conclusion: This study on Acinetobacter bacteraemia in South Sweden found low 30-day mortality and low carbapenem-resistance rates compared to previous international studies which may be due to a higher rate of contaminant findings.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Infection Ecology and Epidemiology
volume
12
issue
1
article number
2009324
publisher
Taylor & Francis
external identifiers
  • pmid:34912503
  • scopus:85121047861
ISSN
2000-8686
DOI
10.1080/20008686.2021.2009324
language
English
LU publication?
yes
id
852da98c-2648-4899-87b6-ac4513d4cd9f
date added to LUP
2021-12-13 11:56:00
date last changed
2025-10-14 11:08:24
@article{852da98c-2648-4899-87b6-ac4513d4cd9f,
  abstract     = {{<p>Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.</p><p>Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.</p><p>Results: There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent risk factors associated with 30-day mortality in the multivariate regression model were Acinetobacter growth in all blood cultures drawn at the day of bacteraemia onset (OR 5.0, 95% CI: 1.8 to 13.7, p= 0.002), baseline functional capacity (1-4 points, OR 2.0, 95% CI: 1.2 to 3.4, p= 0.010) and correct empiric antibiotics at time of culture (OR 3.5 95% CI: 1.0 to 11.8, p= 0.045).</p><p>Conclusion: This study on Acinetobacter bacteraemia in South Sweden found low 30-day mortality and low carbapenem-resistance rates compared to previous international studies which may be due to a higher rate of contaminant findings.</p>}},
  author       = {{Ingefors, Erik and Tverring, Jonas and Nafaa, Fatima and Jönsson, Niklas and Karlsson Söbirk, Sara and Kjölvmark, Charlott and Ljungquist, Oskar}},
  issn         = {{2000-8686}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Taylor & Francis}},
  series       = {{Infection Ecology and Epidemiology}},
  title        = {{Low 30-day mortality and low carbapenem-resistance in a decade of Acinetobacter bacteraemia in South Sweden}},
  url          = {{http://dx.doi.org/10.1080/20008686.2021.2009324}},
  doi          = {{10.1080/20008686.2021.2009324}},
  volume       = {{12}},
  year         = {{2022}},
}