Low 30-day mortality and low carbapenem-resistance in a decade of Acinetobacter bacteraemia in South Sweden
Ingefors, Erik ; Tverring, Jonas LU
; Nafaa, Fatima
; Jönsson, Niklas
; Karlsson Söbirk, Sara
LU
; Kjölvmark, Charlott
LU
and Ljungquist, Oskar
LU
(2022)
In Infection Ecology and Epidemiology
12(1).
- Abstract
Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.
Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.
Results: There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent... (More)
Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.
Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.
Results: There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent risk factors associated with 30-day mortality in the multivariate regression model were Acinetobacter growth in all blood cultures drawn at the day of bacteraemia onset (OR 5.0, 95% CI: 1.8 to 13.7, p= 0.002), baseline functional capacity (1-4 points, OR 2.0, 95% CI: 1.2 to 3.4, p= 0.010) and correct empiric antibiotics at time of culture (OR 3.5 95% CI: 1.0 to 11.8, p= 0.045).
Conclusion: This study on Acinetobacter bacteraemia in South Sweden found low 30-day mortality and low carbapenem-resistance rates compared to previous international studies which may be due to a higher rate of contaminant findings.
(Less)
- author
- Ingefors, Erik
; Tverring, Jonas
LU
; Nafaa, Fatima
; Jönsson, Niklas
; Karlsson Söbirk, Sara
LU
; Kjölvmark, Charlott
LU
and Ljungquist, Oskar
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infection Ecology and Epidemiology
- volume
- 12
- issue
- 1
- article number
- 2009324
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:34912503
- scopus:85121047861
- ISSN
- 2000-8686
- DOI
- 10.1080/20008686.2021.2009324
- language
- English
- LU publication?
- yes
- id
- 852da98c-2648-4899-87b6-ac4513d4cd9f
- date added to LUP
- 2021-12-13 11:56:00
- date last changed
- 2023-03-25 00:40:25
@article{852da98c-2648-4899-87b6-ac4513d4cd9f,
abstract = {{<p>Background: The aim of this study was to provide a descriptive account of carbapenem resistance and risk factors for mortality from invasive Acinetobacter infections in the south of Sweden.</p><p>Methods: Blood isolates with growth of Acinetobacter species between 2010 and 2019 in Skåne county were subtyped using MALDI-TOF and subjected to susceptibility testing against clinically relevant antibiotics. Association between risk factors and 30-day mortality were analysed in univariate and multivariate logistic regression models.</p><p>Results: There were 179 bacteraemia episodes in 176 patients included in the study. The 30-day all-cause mortality was 16%. In all, two percent of Acinetobacter strains were carbapenem resistant. Independent risk factors associated with 30-day mortality in the multivariate regression model were Acinetobacter growth in all blood cultures drawn at the day of bacteraemia onset (OR 5.0, 95% CI: 1.8 to 13.7, p= 0.002), baseline functional capacity (1-4 points, OR 2.0, 95% CI: 1.2 to 3.4, p= 0.010) and correct empiric antibiotics at time of culture (OR 3.5 95% CI: 1.0 to 11.8, p= 0.045).</p><p>Conclusion: This study on Acinetobacter bacteraemia in South Sweden found low 30-day mortality and low carbapenem-resistance rates compared to previous international studies which may be due to a higher rate of contaminant findings.</p>}},
author = {{Ingefors, Erik and Tverring, Jonas and Nafaa, Fatima and Jönsson, Niklas and Karlsson Söbirk, Sara and Kjölvmark, Charlott and Ljungquist, Oskar}},
issn = {{2000-8686}},
language = {{eng}},
number = {{1}},
publisher = {{Taylor & Francis}},
series = {{Infection Ecology and Epidemiology}},
title = {{Low 30-day mortality and low carbapenem-resistance in a decade of Acinetobacter bacteraemia in South Sweden}},
url = {{http://dx.doi.org/10.1080/20008686.2021.2009324}},
doi = {{10.1080/20008686.2021.2009324}},
volume = {{12}},
year = {{2022}},
}