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Familial upper aerodigestive tract cancers : incidence trends, familial clustering and subsequent cancers

Li, Xinjun LU and Hemminki, Kari LU (2003) In Oral Oncology 39(3). p.9-232
Abstract

Familial risks in upper aerodigestive tract cancer have been assessed mainly through case-control studies based on reported but not medically verified cancers in family members. The nationwide Swedish Family-Cancer Database was used to describe the incidence trends for all subsites of upper aerodigestive tract cancer and to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for the cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second primary cancer after upper aerodigestive tract cancers were analysed. SIRs in offspring for all upper aerodigestive tract cancer were not significant when a parent presented with concordant cancer. The population attributable fraction... (More)

Familial risks in upper aerodigestive tract cancer have been assessed mainly through case-control studies based on reported but not medically verified cancers in family members. The nationwide Swedish Family-Cancer Database was used to describe the incidence trends for all subsites of upper aerodigestive tract cancer and to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for the cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second primary cancer after upper aerodigestive tract cancers were analysed. SIRs in offspring for all upper aerodigestive tract cancer were not significant when a parent presented with concordant cancer. The population attributable fraction of familial upper aerodigestive tract cancer was 0.43%. Risk for subsequent cancers in men and women after upper aerodigestive tract cancer were increased in smoking, alcohol and other life-style related sites and in skin cancer and non-Hodgkin's lymphoma.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Aged, Child, Child, Preschool, Cluster Analysis, Databases, Factual, Female, Follow-Up Studies, Head and Neck Neoplasms/epidemiology, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Neoplasms, Second Primary/epidemiology, Neoplastic Syndromes, Hereditary/epidemiology, Registries, Risk Factors, Sex Factors, Sweden/epidemiology
in
Oral Oncology
volume
39
issue
3
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:0037400118
ISSN
1368-8375
DOI
10.1016/S1368-8375(02)00091-X
language
English
LU publication?
no
id
854ae87c-57a7-4127-a4b7-42980c4e324c
date added to LUP
2019-01-30 12:05:41
date last changed
2019-03-05 04:31:19
@article{854ae87c-57a7-4127-a4b7-42980c4e324c,
  abstract     = {<p>Familial risks in upper aerodigestive tract cancer have been assessed mainly through case-control studies based on reported but not medically verified cancers in family members. The nationwide Swedish Family-Cancer Database was used to describe the incidence trends for all subsites of upper aerodigestive tract cancer and to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for the cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second primary cancer after upper aerodigestive tract cancers were analysed. SIRs in offspring for all upper aerodigestive tract cancer were not significant when a parent presented with concordant cancer. The population attributable fraction of familial upper aerodigestive tract cancer was 0.43%. Risk for subsequent cancers in men and women after upper aerodigestive tract cancer were increased in smoking, alcohol and other life-style related sites and in skin cancer and non-Hodgkin's lymphoma.</p>},
  author       = {Li, Xinjun and Hemminki, Kari},
  issn         = {1368-8375},
  keyword      = {Adolescent,Adult,Aged,Child,Child, Preschool,Cluster Analysis,Databases, Factual,Female,Follow-Up Studies,Head and Neck Neoplasms/epidemiology,Humans,Incidence,Infant,Infant, Newborn,Male,Middle Aged,Neoplasms, Second Primary/epidemiology,Neoplastic Syndromes, Hereditary/epidemiology,Registries,Risk Factors,Sex Factors,Sweden/epidemiology},
  language     = {eng},
  number       = {3},
  pages        = {9--232},
  publisher    = {Elsevier},
  series       = {Oral Oncology},
  title        = {Familial upper aerodigestive tract cancers : incidence trends, familial clustering and subsequent cancers},
  url          = {http://dx.doi.org/10.1016/S1368-8375(02)00091-X},
  volume       = {39},
  year         = {2003},
}