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Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Perez-Cornago, Aurora; Appleby, Paul N.; Tipper, Sarah; Key, Timothy J.; Allen, Naomi E.; Nieters, Alexandra; Vermeulen, Roel; Roulland, Sandrine; Casabonne, Delphine and Kaaks, Rudolf, et al. (2017) In International Journal of Cancer 140(5). p.1111-1118
Abstract

Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third=0.77 [95% CI=0.57-1.03],... (More)

Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third=0.77 [95% CI=0.57-1.03], ptrend=0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (pheterogeneity for all≥0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.

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published
subject
keywords
EPIC cohort, IGF-I, Lymphoma, Nested case-control, Non-Hodgkin lymphoma, Plasma, Prospective
in
International Journal of Cancer
volume
140
issue
5
pages
1111 - 1118
publisher
John Wiley & Sons
external identifiers
  • scopus:85007420750
  • wos:000393976100014
ISSN
0020-7136
DOI
10.1002/ijc.30528
language
English
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yes
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855d905b-d6c5-4852-811a-7e86c4b441b6
date added to LUP
2017-01-20 15:12:22
date last changed
2018-05-29 10:31:23
@article{855d905b-d6c5-4852-811a-7e86c4b441b6,
  abstract     = {<p>Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case-control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third=0.77 [95% CI=0.57-1.03], p<sub>trend</sub>=0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (p<sub>heterogeneity for all</sub>≥0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.</p>},
  author       = {Perez-Cornago, Aurora and Appleby, Paul N. and Tipper, Sarah and Key, Timothy J. and Allen, Naomi E. and Nieters, Alexandra and Vermeulen, Roel and Roulland, Sandrine and Casabonne, Delphine and Kaaks, Rudolf and Fortner, Renee T. and Boeing, Heiner and Trichopoulou, Antonia and La Vecchia, Carlo and Klinaki, Eleni and Hansen, Louise and Tjønneland, Anne and Bonnet, Fabrice and Fagherazzi, Guy and Boutron-Ruault, Marie Christine and Pala, Valeria and Masala, Giovanna and Sacerdote, Carlotta and Peeters, Petra H. and Bueno-de-Mesquita, H. Bas and Weiderpass, Elisabete and Dorronsoro, Miren and Quirós, J. Ramón and Barricarte, Aurelio and Gavrila, Diana and Agudo, Antonio and Borgquist, Signe and Rosendahl, Ann H. and Melin, Beatrice and Wareham, Nick and Khaw, Kay Tee and Gunter, Marc and Riboli, Elio and Vineis, Paolo and Travis, Ruth C.},
  issn         = {0020-7136},
  keyword      = {EPIC cohort,IGF-I,Lymphoma,Nested case-control,Non-Hodgkin lymphoma,Plasma,Prospective},
  language     = {eng},
  number       = {5},
  pages        = {1111--1118},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.30528},
  volume       = {140},
  year         = {2017},
}