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Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases.

Eklund, Yvonne LU ; Aronsson, Annika LU ; Schmidtchen, Artur LU and Relander, Thomas LU (2016) In Acta Dermato-Venereologica 96(5). p.669-673
Abstract
Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Forty-four patients with clinically and histopathologically verified MF were identified during the period, with a mean follow-up time of 5.6 years. Median age at initial diagnosis was 64 years. In several cases other skin diseases preceded MF onset, such as non-specific dermatitis (32%) and parapsoriasis (30%). The majority of patients (86%, n = 38) had limited-stage (IA-IB) disease at the time of diagnosis. Overall response rate... (More)
Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Forty-four patients with clinically and histopathologically verified MF were identified during the period, with a mean follow-up time of 5.6 years. Median age at initial diagnosis was 64 years. In several cases other skin diseases preceded MF onset, such as non-specific dermatitis (32%) and parapsoriasis (30%). The majority of patients (86%, n = 38) had limited-stage (IA-IB) disease at the time of diagnosis. Overall response rate to psoralen plus ultraviolet A (PUVA) treatment was 81%. In adnexal MF, a trend to higher rate of progression to an advanced stage was observed when compared with non-adnexal disease (40% and 21%, respectively). Increased levels of soluble interleukin-2 (IL-2) receptor correlated with disease stage, being elevated in advanced stages or adnexal disease, but almost never in early non-adnexal limited-stage disease. Overall mortality was 25%, but only 11% could be verified as caused by MF. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Dermato-Venereologica
volume
96
issue
5
pages
669 - 673
publisher
Medical Journals Limited
external identifiers
  • pmid:26778803
  • scopus:84973623256
  • pmid:26778803
  • wos:000378883900015
ISSN
1651-2057
DOI
10.2340/00015555-2337
language
English
LU publication?
yes
id
28a9901b-765f-4f8e-9639-8affb2c03caf (old id 8577226)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26778803?dopt=Abstract
date added to LUP
2016-04-04 09:12:51
date last changed
2022-04-23 19:25:06
@article{28a9901b-765f-4f8e-9639-8affb2c03caf,
  abstract     = {{Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Forty-four patients with clinically and histopathologically verified MF were identified during the period, with a mean follow-up time of 5.6 years. Median age at initial diagnosis was 64 years. In several cases other skin diseases preceded MF onset, such as non-specific dermatitis (32%) and parapsoriasis (30%). The majority of patients (86%, n = 38) had limited-stage (IA-IB) disease at the time of diagnosis. Overall response rate to psoralen plus ultraviolet A (PUVA) treatment was 81%. In adnexal MF, a trend to higher rate of progression to an advanced stage was observed when compared with non-adnexal disease (40% and 21%, respectively). Increased levels of soluble interleukin-2 (IL-2) receptor correlated with disease stage, being elevated in advanced stages or adnexal disease, but almost never in early non-adnexal limited-stage disease. Overall mortality was 25%, but only 11% could be verified as caused by MF.}},
  author       = {{Eklund, Yvonne and Aronsson, Annika and Schmidtchen, Artur and Relander, Thomas}},
  issn         = {{1651-2057}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{5}},
  pages        = {{669--673}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases.}},
  url          = {{http://dx.doi.org/10.2340/00015555-2337}},
  doi          = {{10.2340/00015555-2337}},
  volume       = {{96}},
  year         = {{2016}},
}