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Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control.

Ahrén, Bo LU (2015) In Diabetes & Metabolism 41(6 Suppl 1). p.3-8
Abstract
Combining insulin with glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase-4 (DPP-4) inhibitors as glucose-lowering therapy for type 2 diabetes is a promising strategy that has gained considerable interest over the past few years. One advantage of this combination is the complementary mechanistic actions of insulin and GLP-1. Insulin increases glucose utilization and retards hepatic glucose production through direct actions in muscle, adipose tissue and the liver. On the other hand, GLP-1 stimulates insulin secretion, inhibits glucagon secretion and retards gastric emptying. Combining these effects results in powerful reductions in both fasting and postprandial glucose through diminished glucose entry into the... (More)
Combining insulin with glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase-4 (DPP-4) inhibitors as glucose-lowering therapy for type 2 diabetes is a promising strategy that has gained considerable interest over the past few years. One advantage of this combination is the complementary mechanistic actions of insulin and GLP-1. Insulin increases glucose utilization and retards hepatic glucose production through direct actions in muscle, adipose tissue and the liver. On the other hand, GLP-1 stimulates insulin secretion, inhibits glucagon secretion and retards gastric emptying. Combining these effects results in powerful reductions in both fasting and postprandial glucose through diminished glucose entry into the bloodstream after food consumption, reduced hepatic production of glucose and increased glucose utilization. In addition, GLP-1 receptor agonists induce satiety, leading to decreases in food intakes and body weight, thereby preventing the weight gain often seen with insulin therapy. Clinical trials have verified that these physiological effects as a result of combining insulin with GLP-1 receptor agonists or DPP-4 inhibitors can indeed result in improved glycaemia, with limited risks of hypoglycaemia and weight gain. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes & Metabolism
volume
41
issue
6 Suppl 1
pages
3 - 8
publisher
Masson Editeur
external identifiers
  • pmid:26774018
  • wos:000368215500002
  • scopus:84953226707
ISSN
1878-1780
DOI
10.1016/S1262-3636(16)30002-7
language
English
LU publication?
yes
id
2da0949e-7a2e-4bb0-bfac-d021949adb2d (old id 8577522)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26774018?dopt=Abstract
date added to LUP
2016-02-10 11:50:39
date last changed
2017-11-05 03:02:58
@article{2da0949e-7a2e-4bb0-bfac-d021949adb2d,
  abstract     = {Combining insulin with glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase-4 (DPP-4) inhibitors as glucose-lowering therapy for type 2 diabetes is a promising strategy that has gained considerable interest over the past few years. One advantage of this combination is the complementary mechanistic actions of insulin and GLP-1. Insulin increases glucose utilization and retards hepatic glucose production through direct actions in muscle, adipose tissue and the liver. On the other hand, GLP-1 stimulates insulin secretion, inhibits glucagon secretion and retards gastric emptying. Combining these effects results in powerful reductions in both fasting and postprandial glucose through diminished glucose entry into the bloodstream after food consumption, reduced hepatic production of glucose and increased glucose utilization. In addition, GLP-1 receptor agonists induce satiety, leading to decreases in food intakes and body weight, thereby preventing the weight gain often seen with insulin therapy. Clinical trials have verified that these physiological effects as a result of combining insulin with GLP-1 receptor agonists or DPP-4 inhibitors can indeed result in improved glycaemia, with limited risks of hypoglycaemia and weight gain.},
  author       = {Ahrén, Bo},
  issn         = {1878-1780},
  language     = {eng},
  number       = {6 Suppl 1},
  pages        = {3--8},
  publisher    = {Masson Editeur},
  series       = {Diabetes & Metabolism},
  title        = {Physiological aspects of the combination of insulin and GLP-1 in the regulation of blood glucose control.},
  url          = {http://dx.doi.org/10.1016/S1262-3636(16)30002-7},
  volume       = {41},
  year         = {2015},
}