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Cylindromatosis-A Protective Molecule against Liver Diseases.

Hellerbrand, Claus and Massoumi, Ramin LU (2016) In Medicinal Research Reviews 36(2). p.342-359
Abstract
Cylindromatosis (CYLD) is a deubiquitination enzyme involved in the regulation of different cellular processes including inflammation, fibrosis, and cancer. The function of CYLD is via deubiquitination of specific substrates in different signaling pathways including NF-κB, Notch, and JNK. CYLD contributes to hepatic homeostasis and restoration upon liver injury. Mutation or disruption of the activity of CYLD in animals aggravates acute as well as chronic liver injury and promotes development and progression of hepatocellular cancer. This is mediated by a shift of the balance toward pro-inflammatory, pro-fibrogenic, and pro-oncogenic pathways. In this review, we will explain the liver-associated signaling pathways that CYLD regulates in... (More)
Cylindromatosis (CYLD) is a deubiquitination enzyme involved in the regulation of different cellular processes including inflammation, fibrosis, and cancer. The function of CYLD is via deubiquitination of specific substrates in different signaling pathways including NF-κB, Notch, and JNK. CYLD contributes to hepatic homeostasis and restoration upon liver injury. Mutation or disruption of the activity of CYLD in animals aggravates acute as well as chronic liver injury and promotes development and progression of hepatocellular cancer. This is mediated by a shift of the balance toward pro-inflammatory, pro-fibrogenic, and pro-oncogenic pathways. In this review, we will explain the liver-associated signaling pathways that CYLD regulates in hepatocytes and nonparenchymal liver cells under physiological and pathological conditions. We will also describe the most recent findings concerning CYLD-mediated downstream signaling in the liver in situations such as injury, infection, inflammation, and cancer. Furthermore, we will discuss the potential of novel diagnostic tools and treatment strategies utilizing CYLD and its target genes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CYLD, Deubiquitination, Hepatic fibrosis, Hepatocellular carcinoma, Liver injury
in
Medicinal Research Reviews
volume
36
issue
2
pages
342 - 359
publisher
John Wiley & Sons
external identifiers
  • pmid:26763122
  • scopus:84958941219
  • wos:000370156700006
ISSN
1098-1128
DOI
10.1002/med.21381
language
English
LU publication?
yes
id
ef56db8f-6c3c-4172-9270-5eb81419cf0b (old id 8592108)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26763122?dopt=Abstract
date added to LUP
2016-02-15 14:49:15
date last changed
2017-01-01 03:44:34
@article{ef56db8f-6c3c-4172-9270-5eb81419cf0b,
  abstract     = {Cylindromatosis (CYLD) is a deubiquitination enzyme involved in the regulation of different cellular processes including inflammation, fibrosis, and cancer. The function of CYLD is via deubiquitination of specific substrates in different signaling pathways including NF-κB, Notch, and JNK. CYLD contributes to hepatic homeostasis and restoration upon liver injury. Mutation or disruption of the activity of CYLD in animals aggravates acute as well as chronic liver injury and promotes development and progression of hepatocellular cancer. This is mediated by a shift of the balance toward pro-inflammatory, pro-fibrogenic, and pro-oncogenic pathways. In this review, we will explain the liver-associated signaling pathways that CYLD regulates in hepatocytes and nonparenchymal liver cells under physiological and pathological conditions. We will also describe the most recent findings concerning CYLD-mediated downstream signaling in the liver in situations such as injury, infection, inflammation, and cancer. Furthermore, we will discuss the potential of novel diagnostic tools and treatment strategies utilizing CYLD and its target genes.},
  author       = {Hellerbrand, Claus and Massoumi, Ramin},
  issn         = {1098-1128},
  keyword      = {CYLD,Deubiquitination,Hepatic fibrosis,Hepatocellular carcinoma,Liver injury},
  language     = {eng},
  number       = {2},
  pages        = {342--359},
  publisher    = {John Wiley & Sons},
  series       = {Medicinal Research Reviews},
  title        = {Cylindromatosis-A Protective Molecule against Liver Diseases.},
  url          = {http://dx.doi.org/10.1002/med.21381},
  volume       = {36},
  year         = {2016},
}