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Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.

Domchek, Susan M; Aghajanian, Carol; Shapira-Frommer, Ronnie; Schmutzler, Rita K; Audeh, M William; Friedlander, Michael; Balmaña, Judith; Mitchell, Gillian; Fried, Georgeta and Stemmer, Salomon M, et al. (2016) In Gynecologic Oncology 140(2). p.199-203
Abstract
The efficacy and safety of olaparib, an oral poly(ADP-ribose) polymerase (PARP) inhibitor, was investigated in a subgroup of patients with germline BRCA1/2 mutated (gBRCA1/2m) advanced ovarian cancer who had received ≥3 prior lines of chemotherapy. Primary data from this Phase II study (Study 42, ClinicalTrials.govNCT01078662) have been reported previously.
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Contribution to journal
publication status
published
subject
in
Gynecologic Oncology
volume
140
issue
2
pages
199 - 203
publisher
Academic Press
external identifiers
  • pmid:26723501
  • scopus:84953204390
  • wos:000369678900003
ISSN
1095-6859
DOI
10.1016/j.ygyno.2015.12.020
language
English
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yes
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daa777d4-7791-4af0-8cab-a193c1fe9991 (old id 8593401)
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http://www.ncbi.nlm.nih.gov/pubmed/26723501?dopt=Abstract
date added to LUP
2016-02-01 19:16:13
date last changed
2017-11-12 04:06:25
@article{daa777d4-7791-4af0-8cab-a193c1fe9991,
  abstract     = {The efficacy and safety of olaparib, an oral poly(ADP-ribose) polymerase (PARP) inhibitor, was investigated in a subgroup of patients with germline BRCA1/2 mutated (gBRCA1/2m) advanced ovarian cancer who had received ≥3 prior lines of chemotherapy. Primary data from this Phase II study (Study 42, ClinicalTrials.govNCT01078662) have been reported previously.},
  author       = {Domchek, Susan M and Aghajanian, Carol and Shapira-Frommer, Ronnie and Schmutzler, Rita K and Audeh, M William and Friedlander, Michael and Balmaña, Judith and Mitchell, Gillian and Fried, Georgeta and Stemmer, Salomon M and Hubert, Ayala and Rosengarten, Ora and Loman, Niklas and Robertson, Jane D and Mann, Helen and Kaufman, Bella},
  issn         = {1095-6859},
  language     = {eng},
  number       = {2},
  pages        = {199--203},
  publisher    = {Academic Press},
  series       = {Gynecologic Oncology},
  title        = {Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy.},
  url          = {http://dx.doi.org/10.1016/j.ygyno.2015.12.020},
  volume       = {140},
  year         = {2016},
}