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A tailored biocompatible neural interface for long term monitoring in neural networks

Köhler, Per LU (2016) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2016:25.
Abstract
Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain parenchyma. To address this challenge, a novel, polymer-based neural probe, with protrusions tailored to the target tissue, was developed to investigate which probe properties affect the development of a glial scar and neuronal cell death surrounding probes. After many cycles of testing – refinements, promising recordings of neural activity were obtained in both cerebellum

and cortex cerebri (papers I-III). In paper IV, we evaluated the... (More)
Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain parenchyma. To address this challenge, a novel, polymer-based neural probe, with protrusions tailored to the target tissue, was developed to investigate which probe properties affect the development of a glial scar and neuronal cell death surrounding probes. After many cycles of testing – refinements, promising recordings of neural activity were obtained in both cerebellum

and cortex cerebri (papers I-III). In paper IV, we evaluated the importance of mechanical flexibility and demonstrated that probe flexibility has a significant impact on the astroglial scar, but not on the loss of neurons nearby. Moreover, by embedding the dummy probes in a gelatin matrix that dissolves shortly following implantation, neuronal cell death surrounding chronically (6 weeks) implanted electrodes was, for the first time, abolished. In paper V, sensory processing in primary somatosensory cortex during an episode of hyperalgesia was monitored using implanted neural interfaces in order to further evaluate the probe functionality and usefulness in neurophysiological research. By tracking the development of primary and secondary hyperalgesia as well as allodynia in the sensory cortex, we demonstrate the usefulness of our new neural interface and its capability to differentially and simultaneously record neural signals in different cortical laminae in awake freely moving animals. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Stieglitz, Thomas, Universität Freiburg
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Brain-machine interfaces, neuroinflammation, somatosensory cortex, hyperalgesia, allodynia
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2016:25
pages
76 pages
publisher
Neuronano Research Center (NRC)
defense location
Belfragesalen, Klinikgatan 32, BMC D15, Lund.
defense date
2016-03-04 09:00
ISSN
1652-8220
ISBN
978-91-7619-248-1
language
English
LU publication?
yes
id
1475f06d-05c8-46b7-a5be-30b5d5e1e793 (old id 8597852)
date added to LUP
2016-02-15 07:48:26
date last changed
2016-09-19 08:44:47
@phdthesis{1475f06d-05c8-46b7-a5be-30b5d5e1e793,
  abstract     = {Neural interface electrodes that can record from neurons in the brain for long periods of time will be of great importance to unravel how the brain accomplishes its functions. However, current electrodes usually cause significant glia reactions and loss of neurons within the adjacent brain parenchyma. To address this challenge, a novel, polymer-based neural probe, with protrusions tailored to the target tissue, was developed to investigate which probe properties affect the development of a glial scar and neuronal cell death surrounding probes. After many cycles of testing – refinements, promising recordings of neural activity were obtained in both cerebellum<br/><br>
and cortex cerebri (papers I-III). In paper IV, we evaluated the importance of mechanical flexibility and demonstrated that probe flexibility has a significant impact on the astroglial scar, but not on the loss of neurons nearby. Moreover, by embedding the dummy probes in a gelatin matrix that dissolves shortly following implantation, neuronal cell death surrounding chronically (6 weeks) implanted electrodes was, for the first time, abolished. In paper V, sensory processing in primary somatosensory cortex during an episode of hyperalgesia was monitored using implanted neural interfaces in order to further evaluate the probe functionality and usefulness in neurophysiological research. By tracking the development of primary and secondary hyperalgesia as well as allodynia in the sensory cortex, we demonstrate the usefulness of our new neural interface and its capability to differentially and simultaneously record neural signals in different cortical laminae in awake freely moving animals.},
  author       = {Köhler, Per},
  isbn         = {978-91-7619-248-1},
  issn         = {1652-8220},
  keyword      = {Brain-machine interfaces,neuroinflammation,somatosensory cortex,hyperalgesia,allodynia},
  language     = {eng},
  pages        = {76},
  publisher    = {Neuronano Research Center (NRC)},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {A tailored biocompatible neural interface for long term monitoring in neural networks},
  volume       = {2016:25},
  year         = {2016},
}