Advanced

NSAIDs and Cardiovascular Diseases : Role of Reactive Oxygen Species

Ghosh, Rajeshwary; Alajbegovic, Azra LU and Gomes, Aldrin V (2015) In Oxidative Medicine and Cellular Longevity 2015.
Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular... (More)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Anti-Inflammatory Agents, Non-Steroidal, Arthritis, Cardiovascular Diseases, Cytochrome P-450 Enzyme System, Humans, Incidence, Lipoxygenase, Mitochondria, NADPH Oxidase, Nitric Oxide Synthase, Reactive Oxygen Species, Xanthine Oxidase, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Oxidative Medicine and Cellular Longevity
volume
2015
pages
25 pages
publisher
Hindawi Publishing Corporation
external identifiers
  • scopus:84943240525
ISSN
1942-0994
DOI
10.1155/2015/536962
language
English
LU publication?
no
id
85a0a3dc-25eb-4f1b-824d-b2597d10525b
date added to LUP
2016-12-08 13:28:04
date last changed
2017-09-17 09:34:03
@article{85a0a3dc-25eb-4f1b-824d-b2597d10525b,
  abstract     = {<p>Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.</p>},
  articleno    = {536962},
  author       = {Ghosh, Rajeshwary and Alajbegovic, Azra and Gomes, Aldrin V},
  issn         = {1942-0994},
  keyword      = {Anti-Inflammatory Agents, Non-Steroidal,Arthritis,Cardiovascular Diseases,Cytochrome P-450 Enzyme System,Humans,Incidence,Lipoxygenase,Mitochondria,NADPH Oxidase,Nitric Oxide Synthase,Reactive Oxygen Species,Xanthine Oxidase,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  pages        = {25},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Oxidative Medicine and Cellular Longevity},
  title        = {NSAIDs and Cardiovascular Diseases : Role of Reactive Oxygen Species},
  url          = {http://dx.doi.org/10.1155/2015/536962},
  volume       = {2015},
  year         = {2015},
}