Advanced

Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life

Lawson, Rachael A; Yarnall, Alison J; Duncan, Gordon W; Khoo, Tien K; Breen, David P; Barker, Roger A LU ; Collerton, Daniel; Taylor, John-Paul and Burn, David J (2014) In Parkinsonism and Related Disorders 20(10). p.5-1071
Abstract

BACKGROUND: Poor quality of life (QoL) is a feature of people with Parkinson's disease (PD) who develop dementia. The relationship between mild cognitive impairment in PD (PD-MCI) and QoL is less clear. To address this, we studied the impact of varying severities of cognitive impairment on QoL in a cohort of non-demented patients with early PD.

METHOD: Patients with newly diagnosed PD (n = 219) and age and sex matched healthy controls (n = 99) completed a schedule of neuropsychological tests, in addition to scales assessing QoL (PDQ-39), depression, sleep, neuropsychiatric symptoms and a clinical examination. The Movement Disorder Society criteria were used to define and classify PD-MCI.

RESULTS: Participants with PD-MCI... (More)

BACKGROUND: Poor quality of life (QoL) is a feature of people with Parkinson's disease (PD) who develop dementia. The relationship between mild cognitive impairment in PD (PD-MCI) and QoL is less clear. To address this, we studied the impact of varying severities of cognitive impairment on QoL in a cohort of non-demented patients with early PD.

METHOD: Patients with newly diagnosed PD (n = 219) and age and sex matched healthy controls (n = 99) completed a schedule of neuropsychological tests, in addition to scales assessing QoL (PDQ-39), depression, sleep, neuropsychiatric symptoms and a clinical examination. The Movement Disorder Society criteria were used to define and classify PD-MCI.

RESULTS: Participants with PD-MCI were significantly older than those with normal cognition, had more severe motor symptoms, scored higher for depression and had poorer quality of life. Logistic regression showed that mild cognitive impairment, independent of other factors, was an indicator of poorer QoL. Using cognitive performance 2.0 standard deviations (SD) below normative data as a cut-off to define PD-MCI, there was a significant difference in QoL scores between patients with PD-MCI and those classified as having normal cognition. Subjects with less severe mild cognitive impairment did not exhibit significant differences in QoL.

CONCLUSIONS: PD-MCI is a significant, independent factor contributing to poorer QoL in patients with newly diagnosed PD. Those classified with greatest impairment (2.0 SD below normal values) have lower QoL. This has implications for clinical practice and future interventions targeting cognitive impairments.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Attention, Executive Function, Female, Humans, Male, Memory, Middle Aged, Mild Cognitive Impairment, Neuropsychological Tests, Parkinson Disease, Predictive Value of Tests, Quality of Life, Space Perception, Statistics, Nonparametric, Journal Article, Research Support, Non-U.S. Gov't
in
Parkinsonism and Related Disorders
volume
20
issue
10
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:84908130426
ISSN
1873-5126
DOI
10.1016/j.parkreldis.2014.07.004
language
English
LU publication?
no
id
85d9141b-e503-4579-b931-51feec6773d4
date added to LUP
2016-11-24 15:10:42
date last changed
2017-11-12 04:26:28
@article{85d9141b-e503-4579-b931-51feec6773d4,
  abstract     = {<p>BACKGROUND: Poor quality of life (QoL) is a feature of people with Parkinson's disease (PD) who develop dementia. The relationship between mild cognitive impairment in PD (PD-MCI) and QoL is less clear. To address this, we studied the impact of varying severities of cognitive impairment on QoL in a cohort of non-demented patients with early PD.</p><p>METHOD: Patients with newly diagnosed PD (n = 219) and age and sex matched healthy controls (n = 99) completed a schedule of neuropsychological tests, in addition to scales assessing QoL (PDQ-39), depression, sleep, neuropsychiatric symptoms and a clinical examination. The Movement Disorder Society criteria were used to define and classify PD-MCI.</p><p>RESULTS: Participants with PD-MCI were significantly older than those with normal cognition, had more severe motor symptoms, scored higher for depression and had poorer quality of life. Logistic regression showed that mild cognitive impairment, independent of other factors, was an indicator of poorer QoL. Using cognitive performance 2.0 standard deviations (SD) below normative data as a cut-off to define PD-MCI, there was a significant difference in QoL scores between patients with PD-MCI and those classified as having normal cognition. Subjects with less severe mild cognitive impairment did not exhibit significant differences in QoL.</p><p>CONCLUSIONS: PD-MCI is a significant, independent factor contributing to poorer QoL in patients with newly diagnosed PD. Those classified with greatest impairment (2.0 SD below normal values) have lower QoL. This has implications for clinical practice and future interventions targeting cognitive impairments.</p>},
  author       = {Lawson, Rachael A and Yarnall, Alison J and Duncan, Gordon W and Khoo, Tien K and Breen, David P and Barker, Roger A and Collerton, Daniel and Taylor, John-Paul and Burn, David J},
  issn         = {1873-5126},
  keyword      = {Aged,Attention,Executive Function,Female,Humans,Male,Memory,Middle Aged,Mild Cognitive Impairment,Neuropsychological Tests,Parkinson Disease,Predictive Value of Tests,Quality of Life,Space Perception,Statistics, Nonparametric,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {10},
  pages        = {5--1071},
  publisher    = {Elsevier},
  series       = {Parkinsonism and Related Disorders},
  title        = {Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life},
  url          = {http://dx.doi.org/10.1016/j.parkreldis.2014.07.004},
  volume       = {20},
  year         = {2014},
}