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Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care

Memon, Ashfaque A LU orcid ; Sundquist, Kristina LU ; Ahmad, Abrar LU orcid ; Wang, Xiao LU ; Hedelius, Anna LU and Sundquist, Jan LU (2017) In Psychiatry Research 254. p.311-316
Abstract

Epidermal growth factor (EGF) and inflammatory markers have been associated with various neuro-psychiatric disorders. However, their role in mild to moderate depression and anxiety patients treated with mindfulness-based group therapy (mindfulness) or cognitive behavioral therapy (CBT) is not known. In this study we analyzed plasma levels of interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hsCRP) and EGF before (baseline) and after treatment (8 weeks) and investigated their role in response to both arms of the treatment. To cover variety of mental symptoms, treatment response was analyzed by four scales, the Montgomery-Åsberg depression rating scale (MADRS), Hospital anxiety and depression scale- Depression (HADS-D) and... (More)

Epidermal growth factor (EGF) and inflammatory markers have been associated with various neuro-psychiatric disorders. However, their role in mild to moderate depression and anxiety patients treated with mindfulness-based group therapy (mindfulness) or cognitive behavioral therapy (CBT) is not known. In this study we analyzed plasma levels of interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hsCRP) and EGF before (baseline) and after treatment (8 weeks) and investigated their role in response to both arms of the treatment. To cover variety of mental symptoms, treatment response was analyzed by four scales, the Montgomery-Åsberg depression rating scale (MADRS), Hospital anxiety and depression scale- Depression (HADS-D) and anxiety (HADS-A) and patients health questionnaire-9. EGF levels were significantly decreased after both mindfulness and CBT and were associated with treatment response on all scales independent of the use of tranquilizers and antidepressant treatment. Moreover, baseline EGF levels were significantly associated only with baseline scores of anxiety scale. Levels of inflammatory markers analyzed in this study, were not significantly associated with treatment response on any scale. Our findings suggest that improvement in symptoms of depression and anxiety after both mindfulness and CBT is associated with changes in EGF levels but not with the inflammatory markers.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Psychiatry Research
volume
254
pages
311 - 316
publisher
Elsevier
external identifiers
  • scopus:85019053533
  • wos:000404498600047
  • pmid:28501736
ISSN
1872-7123
DOI
10.1016/j.psychres.2017.05.012
project
Molecular mechanism associated with response to psychotherapeutic interventions in patients with depression/anxiety in primary care patients
language
English
LU publication?
yes
id
85e1604a-5867-4b6c-b451-f4652f4d7640
date added to LUP
2017-05-24 15:42:25
date last changed
2025-04-14 22:13:45
@article{85e1604a-5867-4b6c-b451-f4652f4d7640,
  abstract     = {{<p>Epidermal growth factor (EGF) and inflammatory markers have been associated with various neuro-psychiatric disorders. However, their role in mild to moderate depression and anxiety patients treated with mindfulness-based group therapy (mindfulness) or cognitive behavioral therapy (CBT) is not known. In this study we analyzed plasma levels of interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hsCRP) and EGF before (baseline) and after treatment (8 weeks) and investigated their role in response to both arms of the treatment. To cover variety of mental symptoms, treatment response was analyzed by four scales, the Montgomery-Åsberg depression rating scale (MADRS), Hospital anxiety and depression scale- Depression (HADS-D) and anxiety (HADS-A) and patients health questionnaire-9. EGF levels were significantly decreased after both mindfulness and CBT and were associated with treatment response on all scales independent of the use of tranquilizers and antidepressant treatment. Moreover, baseline EGF levels were significantly associated only with baseline scores of anxiety scale. Levels of inflammatory markers analyzed in this study, were not significantly associated with treatment response on any scale. Our findings suggest that improvement in symptoms of depression and anxiety after both mindfulness and CBT is associated with changes in EGF levels but not with the inflammatory markers.</p>}},
  author       = {{Memon, Ashfaque A and Sundquist, Kristina and Ahmad, Abrar and Wang, Xiao and Hedelius, Anna and Sundquist, Jan}},
  issn         = {{1872-7123}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  pages        = {{311--316}},
  publisher    = {{Elsevier}},
  series       = {{Psychiatry Research}},
  title        = {{Role of IL-8, CRP and epidermal growth factor in depression and anxiety patients treated with mindfulness-based therapy or cognitive behavioral therapy in primary health care}},
  url          = {{http://dx.doi.org/10.1016/j.psychres.2017.05.012}},
  doi          = {{10.1016/j.psychres.2017.05.012}},
  volume       = {{254}},
  year         = {{2017}},
}