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Control of Dissolved Oxygen in Stirred Bioreactors

Åkesson, Mats LU and Hagander, Per LU (1998) In Report TFRT 7571.
Abstract
This report discusses control of dissolved oxygen in a bioreactor where the oxygen supply is manipulated using the stirrer speed. In batch and fed-batch cultivations the operating conditions change significantly which may cause tuning problems. Analysis using a linearized process model shows that the process dynamics is mainly affected by changes in the volumetric oxygen transfer coefficient $K_La$. % To account for the process variations, a control strategy based on PID control and gain scheduling from the stirrer speed is suggested. This approach is straightforward to implement in an industrial control system. Experimental results from a laboratory reactor are presented.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Book/Report
publication status
published
subject
keywords
Feedback control, dissolved oxygen, stirrer speed, bioreactor, gain scheduling.
in
Report TFRT
volume
7571
publisher
Department of Automatic Control, Lund Institute of Technology (LTH)
ISSN
0280-5316
language
English
LU publication?
yes
id
f3be4419-484f-4bd8-85a5-b233bf67eb2a (old id 8602746)
date added to LUP
2016-02-19 11:13:05
date last changed
2016-04-16 04:50:06
@techreport{f3be4419-484f-4bd8-85a5-b233bf67eb2a,
  abstract     = {This report discusses control of dissolved oxygen in a bioreactor where the oxygen supply is manipulated using the stirrer speed. In batch and fed-batch cultivations the operating conditions change significantly which may cause tuning problems. Analysis using a linearized process model shows that the process dynamics is mainly affected by changes in the volumetric oxygen transfer coefficient $K_La$. % To account for the process variations, a control strategy based on PID control and gain scheduling from the stirrer speed is suggested. This approach is straightforward to implement in an industrial control system. Experimental results from a laboratory reactor are presented.},
  author       = {Åkesson, Mats and Hagander, Per},
  institution  = {Department of Automatic Control, Lund Institute of Technology (LTH)},
  issn         = {0280-5316},
  keyword      = {Feedback control,dissolved oxygen,stirrer speed,bioreactor,gain scheduling.},
  language     = {eng},
  series       = {Report TFRT},
  title        = {Control of Dissolved Oxygen in Stirred Bioreactors},
  volume       = {7571},
  year         = {1998},
}