Control of Dissolved Oxygen in Stirred Bioreactors
(1998) In Technical Reports TFRT-7571- Abstract
- This report discusses control of dissolved oxygen in a bioreactor where the oxygen supply is manipulated using the stirrer speed. In batch and fed-batch cultivations the operating conditions change significantly which may cause tuning problems. Analysis using a linearized process model shows that the process dynamics is mainly affected by changes in the volumetric oxygen transfer coefficient $K_La$. % To account for the process variations, a control strategy based on PID control and gain scheduling from the stirrer speed is suggested. This approach is straightforward to implement in an industrial control system. Experimental results from a laboratory reactor are presented.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8602746
- author
- Åkesson, Mats LU and Hagander, Per LU
- organization
- publishing date
- 1998
- type
- Book/Report
- publication status
- published
- subject
- keywords
- Feedback control, dissolved oxygen, stirrer speed, bioreactor, gain scheduling.
- in
- Technical Reports TFRT-7571
- publisher
- Department of Automatic Control, Lund Institute of Technology (LTH)
- ISSN
- 0280-5316
- language
- English
- LU publication?
- yes
- id
- f3be4419-484f-4bd8-85a5-b233bf67eb2a (old id 8602746)
- date added to LUP
- 2016-04-01 16:45:25
- date last changed
- 2018-11-21 20:43:58
@techreport{f3be4419-484f-4bd8-85a5-b233bf67eb2a, abstract = {{This report discusses control of dissolved oxygen in a bioreactor where the oxygen supply is manipulated using the stirrer speed. In batch and fed-batch cultivations the operating conditions change significantly which may cause tuning problems. Analysis using a linearized process model shows that the process dynamics is mainly affected by changes in the volumetric oxygen transfer coefficient $K_La$. % To account for the process variations, a control strategy based on PID control and gain scheduling from the stirrer speed is suggested. This approach is straightforward to implement in an industrial control system. Experimental results from a laboratory reactor are presented.}}, author = {{Åkesson, Mats and Hagander, Per}}, institution = {{Department of Automatic Control, Lund Institute of Technology (LTH)}}, issn = {{0280-5316}}, keywords = {{Feedback control; dissolved oxygen; stirrer speed; bioreactor; gain scheduling.}}, language = {{eng}}, series = {{Technical Reports TFRT-7571}}, title = {{Control of Dissolved Oxygen in Stirred Bioreactors}}, url = {{https://lup.lub.lu.se/search/files/4770852/8727192.pdf}}, year = {{1998}}, }