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Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study

Chang-Claude, Jenny ; Andrieu, Nadine ; Rookus, Matti ; Brohet, Richard ; Antoniou, Antonis C. ; Peock, Susan ; Davidson, Rosemarie ; Izatt, Louise ; Cole, Trevor and Noguès, Catherine , et al. (2007) In Cancer Epidemiology Biomarkers and Prevention 16(4). p.740-746
Abstract

Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion... (More)

Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.

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Cancer Epidemiology Biomarkers and Prevention
volume
16
issue
4
pages
740 - 746
publisher
American Association for Cancer Research
external identifiers
  • pmid:17416765
  • scopus:34247504165
ISSN
1055-9965
DOI
10.1158/1055-9965.EPI-06-0829
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English
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yes
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860d1822-96f0-46f6-ad29-e64a6b82c915
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2019-01-03 14:04:31
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2019-11-13 05:23:45
@article{860d1822-96f0-46f6-ad29-e64a6b82c915,
  abstract     = {<p>Background: Early menarche and late menopause are important risk factors for breast cancer, but their effects on breast cancer risk in BRCA1 and BRCA2 carriers are unknown. Methods: We assessed breast cancer risk in a large series of 1,187 BRCA1 and 414 BRCA2 carriers from the International BRCA1/2 Carrier Cohort Study. Rate ratios were estimated using a weighted Cox-regression approach. Results: Breast cancer risk was not significantly related to age at menopause {hazard ratio [HR] for menopause below age 35 years, 0.60 [95% confidence interval (95% CI), 0.25-1.44]; 35 to 40 years, 1.15 [0.65-2.04]; 45 to 54 years, 1.02 [0.65-1.60]; ≥55 years, 1.12 [0.12-5.02], as compared with premenopausal women}. However, there was some suggestion of a reduction in risk after menopause in BRCA2 carriers. There was some evidence of a protective effect of oophorectomy (HR, 0.56; 95% CI, 0.29-1.09) and a significant trend of decreasing risk with increasing time since oophorectomy, but no apparent effect of natural menopause. There was no association between age at menarche and breast cancer risk, nor any apparent association with the estimated total duration of breast mitotic activity. Conclusions: These results are consistent with other observations suggesting a protective effect of oophorectomy, similar in relative effect to that in the general population. The absence of an effect of age at natural menopause is, however, not consistent with findings in the general population and may reflect the different natural history of the disease in carriers.</p>},
  author       = {Chang-Claude, Jenny and Andrieu, Nadine and Rookus, Matti and Brohet, Richard and Antoniou, Antonis C. and Peock, Susan and Davidson, Rosemarie and Izatt, Louise and Cole, Trevor and Noguès, Catherine and Luporsi, Elisabeth and Huiart, Laetitia and Hoogerbrugge, Nicoline and Van Leeuwen, Flora E. and Osorio, Ana and Eyfjord, Jorunn and Radice, Paolo and Goldgar, David E. and Easton, Douglas F. and Wagner, Teresa and Korn, Verena and Gerdes, Anne Marie and Olah, Edith and Eyford, Jorunn and Manoukian, Siranonoush and Pierotti, Marco A. and Benitez, Javier and Caldes, Trinidad and De La Hoya, Miguel and Lubinski, Jan and Arver, Brita and Simard, Jacques and Sibille, Catherine and Van Asperen, Christi and Meijers-Heijboer, Hanne and Verhoef, Senno and Vasen, Hans and Ausems, Margreet and Menko, Fred and Gomez-Garcia, Encarna and Cook, Margaret and Engel, Cassandra and Haites, Neva and Gregory, Helen and Morrison, Patrick and McKeown, Carole and Donaldson, Alan and Paterson, Joan},
  issn         = {1055-9965},
  language     = {eng},
  month        = {04},
  number       = {4},
  pages        = {740--746},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers and Prevention},
  title        = {Age at menarche and menopause and breast cancer risk in the International BRCA1/2 Carrier Cohort Study},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-06-0829},
  doi          = {10.1158/1055-9965.EPI-06-0829},
  volume       = {16},
  year         = {2007},
}