Advanced

The impact of Andean Patagonian mycoflora in the search for new lead molecules

Aqueveque, Pedro M.; Leonardo Cespedes, Carlos; Kubo, Isao; Seigler, David S. and Sterner, Olov LU (2017) In Annals of the New York Academy of Sciences 1401. p.5-18
Abstract

Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities. Recently, the incorporation of new technologies for the artificial cultivation of fungi and the use of better equipment to isolate and identify active metabolites has allowed the discovery of leading molecules for the design of new and safer drugs and pesticides. The geographical region including the Patagonian Andes mountains harbors a wide... (More)

Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities. Recently, the incorporation of new technologies for the artificial cultivation of fungi and the use of better equipment to isolate and identify active metabolites has allowed the discovery of leading molecules for the design of new and safer drugs and pesticides. The geographical region including the Patagonian Andes mountains harbors a wide diversity of fungi, many of them still unknown and so far associated with Chilean-Argentinian Andean endemic forests. There have been very few chemical studies of the fungi located in this region. However, those few studies have allowed the discovery of new molecules. We argue that the richness of fungal biodiversity in this region offers an interesting source for the discovery of bioactive molecules for the basic and applied sciences.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Andean mycoflora, Antimicrobial, Bioactive metabolites, Chilean fungi, Fungal metabolites
in
Annals of the New York Academy of Sciences
volume
1401
pages
5 - 18
publisher
New York Academy of Sciences
external identifiers
  • scopus:85021297505
  • wos:000410108700001
ISSN
0077-8923
DOI
10.1111/nyas.13402
language
English
LU publication?
yes
id
86140e10-7e3a-49a1-963b-1c31c963c645
date added to LUP
2017-07-13 08:03:32
date last changed
2018-01-16 13:21:15
@article{86140e10-7e3a-49a1-963b-1c31c963c645,
  abstract     = {<p>Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities. Recently, the incorporation of new technologies for the artificial cultivation of fungi and the use of better equipment to isolate and identify active metabolites has allowed the discovery of leading molecules for the design of new and safer drugs and pesticides. The geographical region including the Patagonian Andes mountains harbors a wide diversity of fungi, many of them still unknown and so far associated with Chilean-Argentinian Andean endemic forests. There have been very few chemical studies of the fungi located in this region. However, those few studies have allowed the discovery of new molecules. We argue that the richness of fungal biodiversity in this region offers an interesting source for the discovery of bioactive molecules for the basic and applied sciences.</p>},
  author       = {Aqueveque, Pedro M. and Leonardo Cespedes, Carlos and Kubo, Isao and Seigler, David S. and Sterner, Olov},
  issn         = {0077-8923},
  keyword      = {Andean mycoflora,Antimicrobial,Bioactive metabolites,Chilean fungi,Fungal metabolites},
  language     = {eng},
  pages        = {5--18},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {The impact of Andean Patagonian mycoflora in the search for new lead molecules},
  url          = {http://dx.doi.org/10.1111/nyas.13402},
  volume       = {1401},
  year         = {2017},
}