Long-term consequences of respiratory syncytial virus acute lower respiratory tract infection in early childhood in Guinea-bissau
(2006) In Pediatric Infectious Disease Journal 25(11). p.1025-1031- Abstract
- AIM: The study aimed to investigate long-term consequences of respiratory syncytial virus (RSV) positive acute lower respiratory tract infection (ALRI) in a low-income country according to severity of the initial infection. DESIGN: The study was a 1:1 matched case-control study of 335 RSV case children and 335 control children. The mean age of RSV ALRI was 0.9 year and at follow-up, 6.8 years. Case children were identified at the hospital and in the community with an antigen and an IgM test to diagnose RSV. Severe RSV infection was defined when a child was treated at the hospital, whereas disease was assumed less severe when a child was diagnosed at home and received no care in the hospital. RESULTS: At follow-up, forced expiratory volume... (More)
- AIM: The study aimed to investigate long-term consequences of respiratory syncytial virus (RSV) positive acute lower respiratory tract infection (ALRI) in a low-income country according to severity of the initial infection. DESIGN: The study was a 1:1 matched case-control study of 335 RSV case children and 335 control children. The mean age of RSV ALRI was 0.9 year and at follow-up, 6.8 years. Case children were identified at the hospital and in the community with an antigen and an IgM test to diagnose RSV. Severe RSV infection was defined when a child was treated at the hospital, whereas disease was assumed less severe when a child was diagnosed at home and received no care in the hospital. RESULTS: At follow-up, forced expiratory volume in 1 second (FEV1) and peak flow were significantly lower in case children (odds ratio [OR] = 0.28; 95% confidence interval [CI] 0.10-0.79), the effect being particularly marked for children with severe RSV. Bronchitis at follow-up was reported more frequently among the case children with severe disease. Fewer case children had a positive skin-prick test for local allergens than control children (OR 0.64; 95% CI = 0.44-0.94). Specific IgE for dust mites and cockroach was elevated (52%) in both case and control children. However, specific IgE to peppertree was higher in the case children (OR 2.18; 95% CI = 1.17-4.07). All identified differences were particularly marked for children with severe RSV. CONCLUSION: Severe RSV infection in infancy was associated with decreased lung function in preschool age in Guinea-Bissau. Children with severe RSV disease had more long-term health problems than children with less severe disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1136070
- author
- Poulsen, Anja ; Stensballe, Lone Graff ; Nielsen, Jens ; Benn, Christine Stabell ; Balde, Aliu ; Roth, Adam LU ; Lisse, Ida Maria and Aaby, Peter
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- RSV, severity, respiratory syncytial virus, lung- function, long-term consequences, Guinea-Bissau, diagnostic method, ALRI, atopy, acute lower respiratory tract infection
- in
- Pediatric Infectious Disease Journal
- volume
- 25
- issue
- 11
- pages
- 1025 - 1031
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:17072125
- scopus:33750445319
- ISSN
- 1532-0987
- DOI
- 10.1097/01.inf.0000243214.80794.3a
- language
- English
- LU publication?
- no
- id
- 8618552a-7fb5-406a-bd37-ac7ce4026560 (old id 1136070)
- date added to LUP
- 2016-04-01 16:52:56
- date last changed
- 2022-01-28 22:50:18
@article{8618552a-7fb5-406a-bd37-ac7ce4026560,
abstract = {{AIM: The study aimed to investigate long-term consequences of respiratory syncytial virus (RSV) positive acute lower respiratory tract infection (ALRI) in a low-income country according to severity of the initial infection. DESIGN: The study was a 1:1 matched case-control study of 335 RSV case children and 335 control children. The mean age of RSV ALRI was 0.9 year and at follow-up, 6.8 years. Case children were identified at the hospital and in the community with an antigen and an IgM test to diagnose RSV. Severe RSV infection was defined when a child was treated at the hospital, whereas disease was assumed less severe when a child was diagnosed at home and received no care in the hospital. RESULTS: At follow-up, forced expiratory volume in 1 second (FEV1) and peak flow were significantly lower in case children (odds ratio [OR] = 0.28; 95% confidence interval [CI] 0.10-0.79), the effect being particularly marked for children with severe RSV. Bronchitis at follow-up was reported more frequently among the case children with severe disease. Fewer case children had a positive skin-prick test for local allergens than control children (OR 0.64; 95% CI = 0.44-0.94). Specific IgE for dust mites and cockroach was elevated (52%) in both case and control children. However, specific IgE to peppertree was higher in the case children (OR 2.18; 95% CI = 1.17-4.07). All identified differences were particularly marked for children with severe RSV. CONCLUSION: Severe RSV infection in infancy was associated with decreased lung function in preschool age in Guinea-Bissau. Children with severe RSV disease had more long-term health problems than children with less severe disease.}},
author = {{Poulsen, Anja and Stensballe, Lone Graff and Nielsen, Jens and Benn, Christine Stabell and Balde, Aliu and Roth, Adam and Lisse, Ida Maria and Aaby, Peter}},
issn = {{1532-0987}},
keywords = {{RSV; severity; respiratory syncytial virus; lung- function; long-term consequences; Guinea-Bissau; diagnostic method; ALRI; atopy; acute lower respiratory tract infection}},
language = {{eng}},
number = {{11}},
pages = {{1025--1031}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Pediatric Infectious Disease Journal}},
title = {{Long-term consequences of respiratory syncytial virus acute lower respiratory tract infection in early childhood in Guinea-bissau}},
url = {{http://dx.doi.org/10.1097/01.inf.0000243214.80794.3a}},
doi = {{10.1097/01.inf.0000243214.80794.3a}},
volume = {{25}},
year = {{2006}},
}