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Second primary malignancies among patients with soft tissue tumors in Sweden

Ji, Jianguang LU orcid and Hemminki, Kari LU (2006) In International Journal of Cancer 119(4). p.909-914
Abstract

Survival from soft tissue tumors (STTs) has been improved because of the successful treatment. One of the late sequelae in STT survivors is the development of a second malignancy. The present study aimed at quantifying risks for second malignancies in patients with STTs, and risks for second STTs after other primary malignancies. Adjusted standardized incidence ratios (SIRs), calculated from the Swedish Family-Cancer Database, were used as a measure of risk. Among 6,671 primary STT patients, a total of 650 second malignancies occurred. Besides second STTs, other cancer sites with an increased SIR were the nervous system, endocrine glands, skin (melanoma and squamous cell carcinoma) and prostate; the risk for non-Hodgkin lymphoma (NHL)... (More)

Survival from soft tissue tumors (STTs) has been improved because of the successful treatment. One of the late sequelae in STT survivors is the development of a second malignancy. The present study aimed at quantifying risks for second malignancies in patients with STTs, and risks for second STTs after other primary malignancies. Adjusted standardized incidence ratios (SIRs), calculated from the Swedish Family-Cancer Database, were used as a measure of risk. Among 6,671 primary STT patients, a total of 650 second malignancies occurred. Besides second STTs, other cancer sites with an increased SIR were the nervous system, endocrine glands, skin (melanoma and squamous cell carcinoma) and prostate; the risk for non-Hodgkin lymphoma (NHL) was also increased. The overall risk of second malignancies decreased in the following order: fibrosarocma (1.63) > myxosarcoma (1.48) > leiomyosarcoma (1.44) > liposarcoma (1.21). An increased risk of second STTs after primary cancers of the bone, ovary, nervous system, cervix, thyroid gland, skin, endometrium, breast, upper aerodigestive tract, and after Hodgkin disease, NHL and leukemia was also noted. This study showed that the incidence of second primary malignancies in patients with STTs was increased, but the SIRs varied among specific cancer sites. Besides therapeutic effects, the associations between STTs and bone and nervous system tumors suggested that cancer syndromes, such as neurofibromatosis type 1 and Li-Fraumeni syndrome, may partly explain the excesses. The associations of STTs with cancers of the skin (squamous cell carcinoma and melanoma) and with NHL may be related to immunodeficiency.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Fibrosarcoma, Rhabdomyosarcoma, Second primary malignancies, Soft tissue tumors
in
International Journal of Cancer
volume
119
issue
4
pages
6 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:16557572
  • scopus:33745895282
ISSN
0020-7136
DOI
10.1002/ijc.21910
language
English
LU publication?
no
id
8662973e-50db-4b4d-b2ba-79705bda7c04
date added to LUP
2019-01-30 10:44:20
date last changed
2024-09-18 12:00:39
@article{8662973e-50db-4b4d-b2ba-79705bda7c04,
  abstract     = {{<p>Survival from soft tissue tumors (STTs) has been improved because of the successful treatment. One of the late sequelae in STT survivors is the development of a second malignancy. The present study aimed at quantifying risks for second malignancies in patients with STTs, and risks for second STTs after other primary malignancies. Adjusted standardized incidence ratios (SIRs), calculated from the Swedish Family-Cancer Database, were used as a measure of risk. Among 6,671 primary STT patients, a total of 650 second malignancies occurred. Besides second STTs, other cancer sites with an increased SIR were the nervous system, endocrine glands, skin (melanoma and squamous cell carcinoma) and prostate; the risk for non-Hodgkin lymphoma (NHL) was also increased. The overall risk of second malignancies decreased in the following order: fibrosarocma (1.63) &gt; myxosarcoma (1.48) &gt; leiomyosarcoma (1.44) &gt; liposarcoma (1.21). An increased risk of second STTs after primary cancers of the bone, ovary, nervous system, cervix, thyroid gland, skin, endometrium, breast, upper aerodigestive tract, and after Hodgkin disease, NHL and leukemia was also noted. This study showed that the incidence of second primary malignancies in patients with STTs was increased, but the SIRs varied among specific cancer sites. Besides therapeutic effects, the associations between STTs and bone and nervous system tumors suggested that cancer syndromes, such as neurofibromatosis type 1 and Li-Fraumeni syndrome, may partly explain the excesses. The associations of STTs with cancers of the skin (squamous cell carcinoma and melanoma) and with NHL may be related to immunodeficiency.</p>}},
  author       = {{Ji, Jianguang and Hemminki, Kari}},
  issn         = {{0020-7136}},
  keywords     = {{Fibrosarcoma; Rhabdomyosarcoma; Second primary malignancies; Soft tissue tumors}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{4}},
  pages        = {{909--914}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Second primary malignancies among patients with soft tissue tumors in Sweden}},
  url          = {{http://dx.doi.org/10.1002/ijc.21910}},
  doi          = {{10.1002/ijc.21910}},
  volume       = {{119}},
  year         = {{2006}},
}