The risk for psychiatric disorders in offspring from thrombosis-prone pedigrees in Sweden : a nationwide family study
Zöller, Bengt LU
; Sundquist, Jan
LU
; Sundquist, Kristina
LU
and Ohlsson, Henrik
LU
(2025)
In Research and practice in thrombosis and haemostasis
9(1).
- Abstract
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: This was a Swedish national family study. We identified a total of 482,184 Swedish pedigrees from the Swedish Multigeneration Register containing a mean of 14.2 parents, aunts/uncles, grandparents, and cousins of a core full-sibship that we termed the pedigree offspring (n = 751,060). We then derived 8 empirical classes of these pedigrees... (More)
Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: This was a Swedish national family study. We identified a total of 482,184 Swedish pedigrees from the Swedish Multigeneration Register containing a mean of 14.2 parents, aunts/uncles, grandparents, and cousins of a core full-sibship that we termed the pedigree offspring (n = 751,060). We then derived 8 empirical classes of these pedigrees based on the density of cases of VTE. The risk was determined in offspring for psychiatric disorders as a function of VTE density in their pedigrees. Diagnoses of VTE and psychiatric disorders (F00-F69) were determined according to the International Classification of Diseases codes in Swedish registers. All results were Bonferroni corrected. Results: Higher VTE density, especially for females in pedigrees, was significantly but weakly associated in the offspring with a higher risk of psychiatric disorders. Moreover, VTE density in pedigrees was significantly associated in the offspring with substance abuse disorders, mood (affective) disorders, neurotic, stress-related, and somatoform disorders, behavioral syndromes associated with psychological disturbances and physical factors, personality disorders of adult personality and behavior, depression, and anxiety disorders. Conclusion: Offspring of pedigrees with a high density of VTE, especially for females, are slightly disadvantaged regarding several psychiatric disorders. VTE shares familial susceptibility, albeit weak, with several psychiatric disorders.
(Less)
- author
- Zöller, Bengt
LU
; Sundquist, Jan
LU
; Sundquist, Kristina
LU
and Ohlsson, Henrik
LU
- organization
- publishing date
- 2025-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- depression, epidemiology, family, mental disorders, venous thromboembolism
- in
- Research and practice in thrombosis and haemostasis
- volume
- 9
- issue
- 1
- article number
- 102692
- publisher
- Wiley
- external identifiers
-
- scopus:85218407932
- pmid:40093964
- ISSN
- 2475-0379
- DOI
- 10.1016/j.rpth.2025.102692
- language
- English
- LU publication?
- yes
- id
- 86a25469-d7d0-4244-a115-4b6df5282857
- date added to LUP
- 2025-07-01 11:30:44
- date last changed
- 2025-07-15 12:15:40
@article{86a25469-d7d0-4244-a115-4b6df5282857,
abstract = {{<p>Background: Psychiatric disorders have been associated with venous thromboembolism (VTE). However, to our knowledge, no nationwide study has examined the familial association between VTE and psychiatric disorders. Objectives: We took a pedigree-based approach and examined the risk of psychiatric disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: This was a Swedish national family study. We identified a total of 482,184 Swedish pedigrees from the Swedish Multigeneration Register containing a mean of 14.2 parents, aunts/uncles, grandparents, and cousins of a core full-sibship that we termed the pedigree offspring (n = 751,060). We then derived 8 empirical classes of these pedigrees based on the density of cases of VTE. The risk was determined in offspring for psychiatric disorders as a function of VTE density in their pedigrees. Diagnoses of VTE and psychiatric disorders (F00-F69) were determined according to the International Classification of Diseases codes in Swedish registers. All results were Bonferroni corrected. Results: Higher VTE density, especially for females in pedigrees, was significantly but weakly associated in the offspring with a higher risk of psychiatric disorders. Moreover, VTE density in pedigrees was significantly associated in the offspring with substance abuse disorders, mood (affective) disorders, neurotic, stress-related, and somatoform disorders, behavioral syndromes associated with psychological disturbances and physical factors, personality disorders of adult personality and behavior, depression, and anxiety disorders. Conclusion: Offspring of pedigrees with a high density of VTE, especially for females, are slightly disadvantaged regarding several psychiatric disorders. VTE shares familial susceptibility, albeit weak, with several psychiatric disorders.</p>}},
author = {{Zöller, Bengt and Sundquist, Jan and Sundquist, Kristina and Ohlsson, Henrik}},
issn = {{2475-0379}},
keywords = {{depression; epidemiology; family; mental disorders; venous thromboembolism}},
language = {{eng}},
number = {{1}},
publisher = {{Wiley}},
series = {{Research and practice in thrombosis and haemostasis}},
title = {{The risk for psychiatric disorders in offspring from thrombosis-prone pedigrees in Sweden : a nationwide family study}},
url = {{http://dx.doi.org/10.1016/j.rpth.2025.102692}},
doi = {{10.1016/j.rpth.2025.102692}},
volume = {{9}},
year = {{2025}},
}