A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population - the Malmo preventive project study
Jujic, Amra LU ; Leosdottir, Margrét LU ; Östling, Gerd LU ; Gudmundsson, Petri ; Nilsson, Peter LU ; Melander, Olle LU
and Magnusson, Martin
LU
(2013)
In BMC Medical Genetics
14.
- Abstract
- Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between rs5068 and cardiac organ damage, i.e. left ventricular hypertrophy, has been accounted for in humans. We sought to explore if rs5068 is associated with left ventricular hypertrophy as measured by echocardiographic examination in a non-diabetic population. Methods: 968 non-diabetic individuals from the Malmo Preventive Project (mean age 67 years;... (More)
- Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between rs5068 and cardiac organ damage, i.e. left ventricular hypertrophy, has been accounted for in humans. We sought to explore if rs5068 is associated with left ventricular hypertrophy as measured by echocardiographic examination in a non-diabetic population. Methods: 968 non-diabetic individuals from the Malmo Preventive Project (mean age 67 years; 31% women) were genotyped and examined with echocardiography. Logistic regression was used to adjust for covariates. Results: The minor allele of rs5068 was associated with decreased prevalence of left ventricular hypertrophy (p = 0.021) after adjustment for sex and age. In the multivariate logistic analysis including; age, sex, systolic blood pressure, antihypertensive and/or cardioprotective treatment, body mass index and fasting plasma glucose, the association of rs5068 with left ventricular hypertrophy was, as expected, attenuated (p = 0.061). Conclusion: In a non-diabetic population, the minor allele of rs5068 was associated with lower left ventricular mass. These findings suggest that rs5068, or genetic variants in linkage disequilibrium, might affect susceptibility to left ventricular hypertrophy and support the possible protective role of natriuretic peptides. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3979037
- author
- Jujic, Amra
LU
; Leosdottir, Margrét
LU
; Östling, Gerd
LU
; Gudmundsson, Petri
; Nilsson, Peter
LU
; Melander, Olle
LU
and Magnusson, Martin
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Medical Genetics
- volume
- 14
- article number
- 64
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000321504800001
- scopus:84879196356
- pmid:23799939
- ISSN
- 1471-2350
- DOI
- 10.1186/1471-2350-14-64
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hypertension and Cardiovascular Disease (013242540), Internal Medicine Research Unit (013242520), Emergency medicine/Medicine/Surgery (013240200)
- id
- 86e374bb-410e-40df-a063-d95a3a1f4be2 (old id 3979037)
- date added to LUP
- 2016-04-01 13:49:27
- date last changed
- 2024-01-09 19:09:19
@article{86e374bb-410e-40df-a063-d95a3a1f4be2,
abstract = {{Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between rs5068 and cardiac organ damage, i.e. left ventricular hypertrophy, has been accounted for in humans. We sought to explore if rs5068 is associated with left ventricular hypertrophy as measured by echocardiographic examination in a non-diabetic population. Methods: 968 non-diabetic individuals from the Malmo Preventive Project (mean age 67 years; 31% women) were genotyped and examined with echocardiography. Logistic regression was used to adjust for covariates. Results: The minor allele of rs5068 was associated with decreased prevalence of left ventricular hypertrophy (p = 0.021) after adjustment for sex and age. In the multivariate logistic analysis including; age, sex, systolic blood pressure, antihypertensive and/or cardioprotective treatment, body mass index and fasting plasma glucose, the association of rs5068 with left ventricular hypertrophy was, as expected, attenuated (p = 0.061). Conclusion: In a non-diabetic population, the minor allele of rs5068 was associated with lower left ventricular mass. These findings suggest that rs5068, or genetic variants in linkage disequilibrium, might affect susceptibility to left ventricular hypertrophy and support the possible protective role of natriuretic peptides.}},
author = {{Jujic, Amra and Leosdottir, Margrét and Östling, Gerd and Gudmundsson, Petri and Nilsson, Peter and Melander, Olle and Magnusson, Martin}},
issn = {{1471-2350}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Medical Genetics}},
title = {{A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population - the Malmo preventive project study}},
url = {{https://lup.lub.lu.se/search/files/3611474/4173516.pdf}},
doi = {{10.1186/1471-2350-14-64}},
volume = {{14}},
year = {{2013}},
}