How to build a lung : latest advances and emerging themes in lung bioengineering
De Santis, Martina M LU
; Bölükbas, Deniz A
LU
; Lindstedt, Sandra
LU
and Wagner, Darcy E
LU
(2018)
In European Respiratory Journal
52.
p.1-19
- Abstract
Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant... (More)
Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant efforts to scale-up cell culture methods to generate adequate cell numbers for human-scale bioengineering approaches. Concomitantly, there have been exciting efforts in designing bioreactors that allow for appropriate cell seeding and development of functional lung tissue over time. This review aims to present the current state-of-the-art progress for each of these areas and to discuss promising new ideas within the field of lung bioengineering.
(Less)
- author
- De Santis, Martina M
LU
; Bölükbas, Deniz A
LU
; Lindstedt, Sandra
LU
and Wagner, Darcy E
LU
- organization
- publishing date
- 2018-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Respiratory Journal
- volume
- 52
- article number
- 1601355
- pages
- 1 - 19
- publisher
- European Respiratory Society
- external identifiers
-
- scopus:85054584068
- pmid:29903859
- ISSN
- 1399-3003
- DOI
- 10.1183/13993003.01355-2016
- language
- English
- LU publication?
- yes
- id
- 86fd5c45-ae9b-44b2-a70a-f03faa621e15
- date added to LUP
- 2018-08-27 14:01:14
- date last changed
- 2024-04-15 10:34:30
@article{86fd5c45-ae9b-44b2-a70a-f03faa621e15,
abstract = {{<p>Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant efforts to scale-up cell culture methods to generate adequate cell numbers for human-scale bioengineering approaches. Concomitantly, there have been exciting efforts in designing bioreactors that allow for appropriate cell seeding and development of functional lung tissue over time. This review aims to present the current state-of-the-art progress for each of these areas and to discuss promising new ideas within the field of lung bioengineering.</p>}},
author = {{De Santis, Martina M and Bölükbas, Deniz A and Lindstedt, Sandra and Wagner, Darcy E}},
issn = {{1399-3003}},
language = {{eng}},
pages = {{1--19}},
publisher = {{European Respiratory Society}},
series = {{European Respiratory Journal}},
title = {{How to build a lung : latest advances and emerging themes in lung bioengineering}},
url = {{http://dx.doi.org/10.1183/13993003.01355-2016}},
doi = {{10.1183/13993003.01355-2016}},
volume = {{52}},
year = {{2018}},
}