Advanced

How to build a lung : latest advances and emerging themes in lung bioengineering

De Santis, Martina M LU ; Bölükbas, Deniz A LU ; Lindstedt, Sandra LU and Wagner, Darcy E LU (2018) In European Respiratory Journal1988-01-01+01:00 52. p.1-19
Abstract

Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant... (More)

Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant efforts to scale-up cell culture methods to generate adequate cell numbers for human-scale bioengineering approaches. Concomitantly, there have been exciting efforts in designing bioreactors that allow for appropriate cell seeding and development of functional lung tissue over time. This review aims to present the current state-of-the-art progress for each of these areas and to discuss promising new ideas within the field of lung bioengineering.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Respiratory Journal1988-01-01+01:00
volume
52
pages
1 - 19
publisher
Eur Respiratory Soc
external identifiers
  • scopus:85054584068
ISSN
1399-3003
DOI
10.1183/13993003.01355-2016
language
English
LU publication?
yes
id
86fd5c45-ae9b-44b2-a70a-f03faa621e15
date added to LUP
2018-08-27 14:01:14
date last changed
2019-02-20 11:24:53
@article{86fd5c45-ae9b-44b2-a70a-f03faa621e15,
  abstract     = {<p>Chronic respiratory diseases remain a major cause of morbidity and mortality worldwide. The only option at end-stage disease is lung transplantation, but there are not enough donor lungs to meet clinical demand. Alternative options to increase tissue availability for lung transplantation are urgently required to close the gap on this unmet clinical need. A growing number of tissue engineering approaches are exploring the potential to generate lung tissue ex vivo for transplantation. Both biologically derived and manufactured scaffolds seeded with cells and grown ex vivo have been explored in pre-clinical studies, with the eventual goal of generating functional pulmonary tissue for transplantation. Recently, there have been significant efforts to scale-up cell culture methods to generate adequate cell numbers for human-scale bioengineering approaches. Concomitantly, there have been exciting efforts in designing bioreactors that allow for appropriate cell seeding and development of functional lung tissue over time. This review aims to present the current state-of-the-art progress for each of these areas and to discuss promising new ideas within the field of lung bioengineering.</p>},
  articleno    = {1601355},
  author       = {De Santis, Martina M and Bölükbas, Deniz A and Lindstedt, Sandra and Wagner, Darcy E},
  issn         = {1399-3003},
  language     = {eng},
  pages        = {1--19},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal1988-01-01+01:00},
  title        = {How to build a lung : latest advances and emerging themes in lung bioengineering},
  url          = {http://dx.doi.org/10.1183/13993003.01355-2016},
  volume       = {52},
  year         = {2018},
}