Etiopathogenesis of insulin autoimmunity.
(2012) In Anatomy Research International 2012.- Abstract
- Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining lymphnodes. Recent data on proinsulin peptide binding to type 1 diabetes-associated HLA-DQ2 and -DQ8 is reviewed and illustrated by molecular modeling. The importance of the cellular immune reaction involving cytotoxic CD8-positive T cells to kill beta cells through Class I MHC is discussed along with speculations of the possible role of B... (More)
- Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining lymphnodes. Recent data on proinsulin peptide binding to type 1 diabetes-associated HLA-DQ2 and -DQ8 is reviewed and illustrated by molecular modeling. The importance of the cellular immune reaction involving cytotoxic CD8-positive T cells to kill beta cells through Class I MHC is discussed along with speculations of the possible role of B lymphocytes in presenting the proinsulin autoantigen over and over again through insulin-carrying insulin autoantibodies. In contrast to autoantibodies against other islet autoantigens such as GAD65, IA-2, and ZnT8 transporters, it has not been possible yet to standardize the insulin autoantibody test. As islet autoantibodies predict type 1 diabetes, it is imperative to clarify the mechanisms of insulin autoimmunity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2609015
- author
- Kanatsuna, Norio LU ; Papadopoulos, George K ; Moustakas, Antonis K and Lenmark, Ake
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Anatomy Research International
- volume
- 2012
- article number
- 457546
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:22567309
- pmid:22567309
- ISSN
- 2090-2751
- DOI
- 10.1155/2012/457546
- language
- English
- LU publication?
- yes
- id
- 87262d56-d811-454b-b1eb-387180b5555b (old id 2609015)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22567309?dopt=Abstract
- date added to LUP
- 2016-04-01 10:52:24
- date last changed
- 2018-11-21 19:52:01
@article{87262d56-d811-454b-b1eb-387180b5555b,
abstract = {{Autoimmunity against pancreatic islet beta cells is strongly associated with proinsulin, insulin, or both. The insulin autoreactivity is particularly pronounced in children with young age at onset of type 1 diabetes. Possible mechanisms for (pro)insulin autoimmunity may involve beta-cell destruction resulting in proinsulin peptide presentation on HLA-DR-DQ Class II molecules in pancreatic draining lymphnodes. Recent data on proinsulin peptide binding to type 1 diabetes-associated HLA-DQ2 and -DQ8 is reviewed and illustrated by molecular modeling. The importance of the cellular immune reaction involving cytotoxic CD8-positive T cells to kill beta cells through Class I MHC is discussed along with speculations of the possible role of B lymphocytes in presenting the proinsulin autoantigen over and over again through insulin-carrying insulin autoantibodies. In contrast to autoantibodies against other islet autoantigens such as GAD65, IA-2, and ZnT8 transporters, it has not been possible yet to standardize the insulin autoantibody test. As islet autoantibodies predict type 1 diabetes, it is imperative to clarify the mechanisms of insulin autoimmunity.}},
author = {{Kanatsuna, Norio and Papadopoulos, George K and Moustakas, Antonis K and Lenmark, Ake}},
issn = {{2090-2751}},
language = {{eng}},
publisher = {{Hindawi Limited}},
series = {{Anatomy Research International}},
title = {{Etiopathogenesis of insulin autoimmunity.}},
url = {{https://lup.lub.lu.se/search/files/2201510/3364910.pdf}},
doi = {{10.1155/2012/457546}},
volume = {{2012}},
year = {{2012}},
}