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How should antibodies against P. falciparum merozoite antigens be measured?

Chuangchaiya, S. and Persson, Kristina LU (2013) In Journal of Tropical Medicine
Abstract
Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of affinity of antibodies and what can be done to improve these assays, thereby increasing the knowledge about the immune status of an individual, and to perform better evaluation of vaccine trials.
Please use this url to cite or link to this publication:
author
and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antibody, antigen, malaria vaccine, merozoite antigen, unclassified drug
in
Journal of Tropical Medicine
article number
493834
publisher
Hindawi Limited
external identifiers
  • scopus:84877258320
  • pmid:23690791
ISSN
1687-9686
DOI
10.1155/2013/493834
language
English
LU publication?
no
id
2c707369-d30d-40b5-ad6f-5aa0b01f2851 (old id 8726813)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23690791
date added to LUP
2016-04-01 14:26:08
date last changed
2020-01-12 16:01:43
@article{2c707369-d30d-40b5-ad6f-5aa0b01f2851,
  abstract     = {Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of affinity of antibodies and what can be done to improve these assays, thereby increasing the knowledge about the immune status of an individual, and to perform better evaluation of vaccine trials.},
  author       = {Chuangchaiya, S. and Persson, Kristina},
  issn         = {1687-9686},
  language     = {eng},
  publisher    = {Hindawi Limited},
  series       = {Journal of Tropical Medicine},
  title        = {How should antibodies against P. falciparum merozoite antigens be measured?},
  url          = {https://lup.lub.lu.se/search/ws/files/3975603/8726831},
  doi          = {10.1155/2013/493834},
  year         = {2013},
}